Five volunteers participated in two separate experiments where whole saliva was collected without stimulation or with stimulation by chewing on paraffin wax. The saliva was collected continuously for 120 min after ingestion of 1 mg fluoride as NaF. Blood was collected at intervals throughout the experiments. The results showed that the concentration of fluoride in whole saliva mirrored the fluoride concentration in plasma, but at a lower level. Variations in salivary flow rate (0.34 ± 0.15 ml/min for unstimulated and 1.06 ± 0.28 ml/ min for stimulated) did not affect the salivary fluoride concentration. The amount of fluoride excreted into stimulated whole saliva was significantly correlated with the salivary flow rate, with a correlation coefficient of 0.98. The fraction of the ingested fluoride dose recovered in whole saliva within 2 h was 0.05 ± 0.02 and 0.18 ± 0.09 % for the unstimulated and the stimulated whole saliva, respectively.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.