This study was designed to assess the effect of flavour and detergent in NaF and MFP dentifrices on the availability of fluoride in whole saliva after toothbrushing. Saliva samples were collected in 13 subjects at different times up to 60 min after brushing with controlled amounts of dentifrices with various compositions. The availability of fluoride in whole saliva was determined in terms of areas under the elimination curves (AUC) after linearization of the data by application of the Weibull function. This distribution provided the best quality of fit of all individual elimination data in contrast to commonly used data transformations. Analyses of variance showed a highly significant effect of individuals on the AUC values. Addition of flavour consistently reduced the AUCs whereas addition of detergent always increased the AUCs. The detergent had a negative effect on the observed intraoral hydrolysis of MFP. It was suggested that F–– AUC is a fundamental parameter for the cariostatic potential of F dentifrices.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.