Bovine dental enamel was demineralized in Ca- and phosphate-containing acetate buffers at pH 4.5, with and without albumin and fluoride. Demineralization in albumin-free solutions was followed by albumin treatment at pH 6.8 or 4.7. The mineral loss during demineralization was markedly reduced by the presence of albumin in the solution. Experiments with 14C-albumin showed qualitatively that the albumin penetrated about 100–120 μm into the porous enamel. The protein uptake after demineralization was pH-dependent: at pH 6.8 less albumin was taken up compared with at pH 4.7. The quantitative uptake during demineralization was comparable with the uptake after demineralization at pH 4.7. The albumin uptake showed a linear relationship with the concentration of protein in solution, both during and after demineralization. There was no measurable influence of fluoride on the quantitative albumin uptake during demineralization.

Keywords:
Albumin uptake, Demineralization Enamel
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© 1987 S. Karger AG, Basel
1987
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