The fluoride concentration in whole saliva and the effect of variations in salivary flow rate were studied in 5 volunteers after use of a chewing gum (Fluomin®) containing 0.25 mg fluoride as sodium fluoride. Basal fluoride concentration during 2 consecutive days ranged between 0.3 and 1.1 μmol/l. The salivary fluoride clearance was studied after chewing one piece of the gum. The clearance of fluoride showed three phases in the decline of the curve. The effect of multiple dosing of the fluoride gum was studied for 7 days, one piece of gum was chewed every 2nd hour during the day and whole saliva was sampled frequently. The subjects with a stimulated salivary flow rate ranging between 0.9 and 2.5 ml/min had a mean steady-state level of fluoride in the saliva ranging from 0.7 to 1.6 μmol/l. This was in contrast to the subjects with low salivary flow rate ranging between 0.4 and 0.6 ml/min, where the fluoride concentration ranged from 4.7 to 19.2 μmol/l. In a separate study, the fluoride concentration in plasma in 4 subjects was studied for 24 h following repeated use of 0.5 mg fluoride as two pieces of the gum 10 times a day. The plasma levels found ranged from 1 to 3 μmol/l.

Keywords:
Chewing gum, Clearance, salivary, Flow rate, salivary, Fluoride, Plasma, Saliva
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© 1987 S. Karger AG, Basel
1987
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