L-Sorbose, a ketohexose isomeric with fructose, is one of a group of hypoacidogenic sugars with potential utility as a sucrose alternative in confectionery. In the present study, Streptococcus mutans and Streptococcus milleri were grown in pure continuous culture under glucose-limited conditions in a chemically defined medium at a dilution rate of D = 0.1 h––1. Such conditions were aimed at simulating those thought to occur in dental plaque. Cultures were exposed to transient excesses of sorbose and/or glucose such as might occur at or inbetween meals. The presence of sorbose did not affect the normal response of S. mutans to excess glucose but, in higher concentrations, it reduced both acid production and growth – possibly via a futile cycle – and the organism began to wash out. Sorbose had no effect on S. milleri, which might give this organism an ecological advantage in plaque exposed to sorbose. Further studies on this potential sugar substitute seem warranted.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.