A Knoop hardness indenter has been used to evaluate the ability of toothpastes containing fluoride to assist the rehardening of human enamel in vitro. Measurements were made on enamel specimens before the first and after the last cycle of an 8-cycle protocol of de- and remineralisation which was designed to simulate an inhibited progress towards a lesion. The toothpastes were ranked by comparing the relative fall in hardness of the enamel specimens. A toothpaste containing calcium glycerophosphate (CaGP) was found to be superior to all others tested including an identical formulation lacking only the CaGP. It is concluded that CaGP is a valuable ingredient able to assist the rehardening process in demineralised enamel.

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