The present work was carried out to modify a self-gelling liquid composition for fluoride application to teeth so it would gel with reduced fluoride content. Past work had shown that quaternary ammonium compounds with carbon chain lengths in the C12 to C16 range or surface modifiers such as hydroxylamine-HCl in conjunction with surfactants facilitated gelation in systems of tetraethoxysilane and aqueous sodium fluoride solutions containing 1,900 ppm or more fluoride. A search was conducted among amines, imines and heterocyclic compounds for agents that would facilitate gelation in systems with lower fluoride concentrations. The findings were that imidazole-HCl in conjunction with a surfactant could effect gelation within minutes in systems with as little as 100 ppm fluoride and, further, that gelation of such systems was not affected by the presence of a series of disinfectants, antibiotics or hormones. Thus, it appears that the self-gelling system may be used as a vehicle for medicaments other than fluoride.

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