Aqueous extracts, 1% (w/v), of Nigerian chewing sticks derived from the African plants Serindeia warnecki, Prosopsis africana, Pseudocedrela kotschyi, and Anoigeissus schrimperi were found to effectively inhibit the attachment of S. mutans 6715wt13 to glass or saliva-coated hydroxy-apatite beads. It was shown that the active compounds in these extracts interfere with binding of the bacteria, resulting in reduced adherence. Although no large effect upon the total extracellular glucan synthesis was noted, there was a 15% reduction in the water-insoluble polysaccharide synthesis. Chemical and spectral analysis of the active constituent from S. warnecki showed this material to have the characteristics of a high molecular weight polyphenolic tannin. 1% aqueous solution of tannic acid was also shown to promote similar in vitro adherence inhibition as the tannin-like substance from S. warnecki. In conclusion, the results imply that chewing stick constituents appear to play an important role in restricting plaque accumulation and caries incidence.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.