Four groups of Wistar rats, 10–12 animals per group, were fed a diet containing: (1) sucrose, 56%; (2) highly hydrolysed starch hydrolysate (Lycasin®), 32%, and unmodified starch, 24%; (3) slightly hydrolysed Lycasin, 32%, and unmodified starch, 24%, and (4) unmodified starch, 56%. All animals were infected with a mixture of four strains of Streptococcus mutans and were kept on the diet by use of an automatic feeding machine for 60 days. The caries activity was higher in the sucrose group in fissures as well as on smoth surfaces than in all the three other groups (p < 0.001). With a few exceptions only enamel lesions and slight dentine lesions on the sulcal surfaces were found in the animals fed Lycasin or starch. There was a slight tendency (p < 0.05) to higher caries scores in the group fed the highly hydrolysed Lycasin, containing 38% free sorbitol, than in the group fed the starch hydrolysate with only 12% free sorbitol (slightly hydrolysed Lycasin). These differences in the cariogenicity between highly and slightly hydrolysed Lycasin are discussed concerning oral conditions in man.

Keywords:
Cariogenic diet, Dental caries, Rodents, Starch, Streptococcus mutans, Sugar alcohols
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© 1978 S. Karger AG, Basel
1978
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