A simple and rapidly setting fissure sealant was developed using thixotropic ethyl 2-cyanoacrylate: before application, the sealant containing 10–20 parts of colloid-sized silica, is placed on a small amount of dimethylformamide as a mild initiator, mixed and then applied by brush to the occlusal surface treated with 3 M phosphoric acid for 30 sec. The applied sealant is instantaneously hardened by dropping the setter consisting of ethyl alcohol containing 1% (v/v) of dimethyl p-toluidine. The sealant has the mean tensile bond strengths of 90–150 kg/ cm2 to etched bovine enamel, depending on the composition and acid-conditioning after immersion in water at 37 °C for 24 h.

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