The interaction between solutions of commercial monofluorophosphate (FPO32––) and amorphous and apatitic calcium phosphates was investigated at pH’s 4, 5, and 7. The affinity between FPO32–– and apatite is minimal at pH 7 but materially increases with decreasing pH. Coupled with this greater uptake, however, is an increasing propensity for hydrolytic breakdown to orthophosphate and F1––. The strong interactions of free F1–– and condensed phosphate contaminants with apatite do not appear to modify the weak FPO32–– attraction toward apatite at pH 7. Both the F1–– impurity initially present and the F1–– released by FPO32–– hydrolysis promote the formation of more stable F-containing apatites. This latter reaction may be the responsible factor for the caries-inhibiting effect of FPO32––

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