... verapamil in non-advanced dilated cardiomyopathy (DCM). Methods: This was a randomised trial of 70 DCM patients treated with carvedilol (36 patients) and verapamil (instead of β-blocker; 34 patients) for 12 months. The remaining heart failure (HF) therapy was constant in both groups. The primary outcomes...

... with a decreased ICa,L, and frequently provoked EADs were the typical electrophysiological alterations in the myocytes of MODS dogs. The action potential prolongation was shortened, the ICa,L blocked and EAD suppressed by using verapamil (100 μmol/l) in the myocytes of MODS dogs (66%; 4 of 6). Conclusion...

...-chest experiments in 10 mongrel dogs. Pressures were recorded during control, volume load and after verapamil administration. The relaxation time constant (τ) was determined by fitting a monoexponential with offset to the isovolumic relaxation period of the ENDO, EPI and left ventricular pressure (LVP...

...Ioannis Rizos; Karl-Heinz Seidl; Isaac Aidonidis; Sotiris Stamou; Jochen Senges; Pavlos Toutouzas The effects of i.v. diltiazem (0.25 mg/kg) and i.v. verapamil (0.15 mg/kg) were studied in 18 patients with recurrent paroxysmal supraventricular tachycardia (SVT) who underwent serial...

... had their initial SVT episode before 15 years of age were retrospectively studied (2-228 follow-up months; median, 215 months). Concomitantly congestive heart failure was present in 14 (16%) patients, and a cerebrovascular accident occurred in 1 patient. Intravenous verapamil was most frequently used...

...Cesare Cuspidi; Lorena Sampieri; Lea Boselli; Renato Bragato; Laura Lonati; Monica Bocciolone; Gastone Leonetti; Alberto Zanchetti The aim of this study has been to analyze the acute and chronic effects of oral verapamil on diastolic function indices, derived from Doppler echocardiography, and left...

...A. Friedensohn; R. Meshulam; Z. Schlesinger The antianginal and anti-ischemic efficacy of isosorbide dinitrate (ISDN) retard 120, verapamil 120 sustained-release (s.r.) and their combination was evaluated in 30 patients with chronic angina pectoris. The study was a randomized, double-blind...

... was neither terminated nor prevented by therapy with multiple class I and class III antiarrhythmic drugs. In contrast, ventricular tachycardia was repeatedly terminated within a few minutes following intravenous administration of 10 mg verapamil and did not recur during oral therapy with verapamil (360 mg...

...Jean-Paul Clozel The haemodynamic effects of the two calcium antagonists, tiapamil and verapamil, were compared in conscious rats with or without myocardial infarction. In control rats without myocardial infarction, verapamil was about 20 times more potent than tiapamil to reduce arterial blood...

...Y. Hasin; M. Kriwisky; M.S. Gotsman We compared the effects of verapamil to high dose procainamide on the rate of inducible and spontaneously occurring ventricular tachycardia (VT) in 10 patients. Verapamil induced a significant increase in the rate of tachycardia (R-R interval decreased from 278...

...Amir Pelleg; Yosef Pardo; Bernard Belhassen; Boris Shargordsky; Avri Chagnac; Shlomo Laniado The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model. The control group consisted of 27 dogs. 30...

...F. Franchi; G. Fabbri; A. Monopoli; D. Rossi; L. Matassi; G. Strazzulla; G. Bisi In order to try and evaluate through what prevailing mechanism verapamil (V) can induce an improvement in left ventricular (LV) diastolic early filling in mild to moderate essential hypertension, 43 properly classified...

..., or hypertension nifedipine may be the drug of choice. In contrast verapamil merits choice when supra-ventricular tachycardia is present. Diltiazem appears intermediate between nifedipine and verapamil and may be particularly useful when hypotension or other side effects must be avoided. 11 11 2008 ©...

... before, during and for 9 min after 1 mg/kg tiapamil or 0.13 mg/kg verapamil, given intravenously according to a randomization schedule. Heart rate increased and systolic blood pressure decreased slightly but significantly. A significant improvement in myocardial function, with a decrease in PEP and PEP...

...G. Wendt The main pathways of biotransformation of tiapamil and basic pharmacokinetic information on the drug are presented and compared with those of verapamil. Both compounds are metabolized by similar pathways consisting mainly of N- and O-dealkylation. In man, the two main metabolites...

... intravenous administration of either isotonic saline as placebo, tiapamil (1.1 and 1.6 mg/kg) or verapamil (0.07 and 0.14 mg/kg).It was shown that there was a marked dose-related reduction in peripheral vascular resistance with a maximum effect occurring at 2-5 min after the intravenous administration...

...Maarten L. Simoons; K. Balakumaran Changes in the exercise ECG caused by five different drugs are presented. Analysis of these changes indicate that these are related to the hemodynamic effects of the drugs, rather than to reduction of myocardial ischemia. Calcium antagonists (Verapamil) as well...

...Marilyn E. Hess; Bradley E. Gabel Isolated, perfused rat hearts were used to study the effects of verapamil, excess calcium ions or excess magnesium ions on changes in heart cyclic AMP and myocardial force of contraction. Verapamil caused a dose-dependent decrease in force of contraction...

... Verapamil Digitalis Neo-ajmaline Abstract. The electrocardiograms of 80 ambulatory patients receiving antiar­ rhythmic therapy were supervised with the help of a transtelephonc monitoring system. The patients used a pocket-size modulator and reported several times daily to the receiving center...

...P. Rossi; A. Giordano; A. Tamiz; B. Schiavo; G. Minuco Physical training causes an increase of aerobic capacity in normal and cardiac patients. The influences of training plus placebo and training plus verapamil have been studied in a double-blind randomized trial on 40 patients recovering from...