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Keywords: Tiapamil
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Journal Articles
Journal: Cardiology
Cardiology (1988) 75 (3): 161–169.
Published Online: 11 November 2008
...Jean-Paul Clozel The haemodynamic effects of the two calcium antagonists, tiapamil and verapamil, were compared in conscious rats with or without myocardial infarction. In control rats without myocardial infarction, verapamil was about 20 times more potent than tiapamil to reduce arterial blood...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 172–180.
Published Online: 07 November 2008
...S. Dubner; G. Gimeno; B. Elencwajg; R. Quinteiro; J. Tronge; C. Bertolasi The efficacy of intravenously administered tiapamil in treating premature ventricular contractions (PVCs) in the acute phase of acute myocardial infarction was evaluated in 20 patients using 24-hour continuous ECG monitoring...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 99–104.
Published Online: 07 November 2008
...D. Chu; D. De Gori The antihypertensive effects of intravenously and orally administered tiapamil and placebo were compared in 6 male patients (60 ± 5 years; mean ± SD) with mild essential hypertension (WHO classification Stage I) in a randomized double-blind crossover procedure. In the intravenous...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 79–84.
Published Online: 07 November 2008
...S. Braun; H. Miller; R. Terdiman; S. Laniado Tiapamil has been extensively investigated for treatment of cardiac arrhythmias. Concern persists, however, that, as a calcium antagonist, it may seriously depress myocardial function. To investigate this possibility, 20 patients were given tiapamil...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 157–164.
Published Online: 07 November 2008
...W.F. List; H. Metzler Tiapamil was effectively used in 32 surgical patients in the treatment of intra-and postoperative cardiac arrhythmias such as atrial fibrillation, supraventricular paroxysmal tachycardia and extrasystoles and in ventricular ectopic beats. In 28 patients aged between 38 and 82...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 209–224.
Published Online: 07 November 2008
...S. Gasic In open and double-blind trials, tiapamil was given intravenously and/or orally to 22 patients with coronary heart disease and exertional angina. Multistage bicycle exercise tests were performed before and after drug treatment and patients acted as their own controls. Thallium-201 exercise...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 124–129.
Published Online: 07 November 2008
... performed before and 10 min after 1 or 1.5 mg/kg i.v. tiapamil. In addition, arterial blood pressure was recorded. P-R interval increased from a mean value of 153 ± 36 to 168 ± 49 ms (p < 0.05) due to an increase in the A-H time from 88 ± 19 to 97 ± 23 ms (p < 0.05). Arterial blood pressure and heart...
Journal Articles
Journal Articles
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 199–208.
Published Online: 07 November 2008
...J. Lessem The antiarrhythmic effects of tiapamil were investigated in 48 patients, mean age 54, with acute myocardial infarction and ventricular arrhythmias. 9 had ventricular tachycardia, 6 ventricular fibrillation, and 33 multifocal premature ventricular contractions. Before and after therapy...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 140–143.
Published Online: 07 November 2008
... from any ideas, methods, instructions or products referred to in the content or advertisements. Calcium ion antagonists Tiapamil Cardiac arrhythmias Antiarrhythmic Properties Cardiology 69 (Suppl. 1): 140-143 (1982) Calcium Ion Antagonists in Supraventricular and Ventricular Arrhythmias L...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 58–67.
Published Online: 07 November 2008
...G.G. Rogers; C. Rosendorff; C.J. Shimell; A. Coull We studied the effects of tiapamil during myocardial infarction in the anaesthetized baboon. 10 animals received placebo and 8 animals the drug. After basal measurements the left anterior descending coronary artery was ligated. Measurements were...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 187–191.
Published Online: 07 November 2008
...C. Strozzi; C. Sfrisi; F. Leutenegger; A. Padula; R. Bulgarelli 18 patients with acute myocardial infarction and sustained supra ventricular arrhythmias were treated with tiapamil, in a dose of 1 mg/kg i.v. The drug was effective, i.e., the heart rate was reduced to less than 90 beats/min in 9...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 144–148.
Published Online: 07 November 2008
...B. Brisse; F. Bender; H. Bramann; H. Kuhs; G. Schwippe 37 patients with either chronic atrial fibrillation (AF), atrial premature beats (APBs) or ventricular premature beats (VPBs) received tiapamil as antiarrhythmic treatment. Tiapamil reduced A-V conduction by an average 20% in the group with AF...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 68–78.
Published Online: 07 November 2008
...G. Wendt The main pathways of biotransformation of tiapamil and basic pharmacokinetic information on the drug are presented and compared with those of verapamil. Both compounds are metabolized by similar pathways consisting mainly of N- and O-dealkylation. In man, the two main metabolites...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 165–171.
Published Online: 07 November 2008
...F. Burkart; G. Baitsch; S. Braun; O. Bertel; G. Cocco 57 patients were admitted to the study, 3-6 weeks after acute myocardial infarction. They received either placebo or 1 mg/kg tiapamil intravenously according to a randomized, double-blind procedure. The study had two objectives: (a) to assess...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 192–198.
Published Online: 07 November 2008
...T. Menzel; P. Kirchner 27 cardiac patients with different types of arrhythmias were treated in the coronary care unit with tiapamil administered by intravenous infusion. Special attention was given to determining the antiarrhythmic effects in patients with acute coronary insufficiency. In the group...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 85–90.
Published Online: 07 November 2008
... intravenous administration of either isotonic saline as placebo, tiapamil (1.1 and 1.6 mg/kg) or verapamil (0.07 and 0.14 mg/kg).It was shown that there was a marked dose-related reduction in peripheral vascular resistance with a maximum effect occurring at 2-5 min after the intravenous administration...
Journal Articles
Journal: Cardiology
Cardiology (1982) 69 (Suppl. 1): 31–57.
Published Online: 07 November 2008
...G. Haeusler; R. Eigenmann; M. Gerold; F. Hefti; D. Jovanovic; L. Blaber; K. Nakamura; S. Thorens The results obtained in a variety of isolated organ preparations characterize tiapamil as a calcium antagonist or calcium entry blocker. Tiapamil inhibited in a concentration-dependent manner calcium...