... those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety...

... that the individual response to a LDL-C lowering drug can vary considerably. Bempedoic acid has a favorable safety profile, particularly it does not induce muscle problems because its precursor is not metabolized to the active drug in the muscle, and it does not induce hyperglycemia. Bempedoic acid probably is best...

... assessed the safety and effectiveness of vernakalant when used in the emergency department setting (ED group) or in an inpatient hospital setting (non-ED group). Methods: This post hoc analysis of the international, observational, post-authorization SPECTRUM study included 1,289 and 720 recent-onset AF...

... of cardioversion safety. Based on retrospective subgroup analyses and prospective studies, non-vitamin K anticoagulants are at least as efficient as vitamin K-antagonists in preventing thromboembolic complications after cardioversion. The risk of thromboembolic complications after cardioversion very much depends...

... events Safety Registry Unfortunately, randomized trials with clopidogrel, prasugrel, or ticagrelor provide scarce adverse events reporting, and these are usually limited to the associated bleeding risks. Since posttrial safety data are not collected systematically, sources of comorbidities...

...Ting Cui; Wanfeng Sun; Yanhong He; Guopei Zhang; Dajie Wang; Yudong Xia; Feng Wang; Mingxing Zhu Background: To investigate the feasibility and safety of the O eccentric shape occluder in the interventional occlusion treatment of intracristal ventricular septal defect (IVSD). Methods...

... Efficacy Safety Carvedilol Abstract The search for the ideal antihypertensive drug is ongoing. Since hypertension initially is a relatively symptom-free dis­ ease, it is important that any agent developed be not only effi­ cacious but also safe, with minimal side effects. Additionally such a drug should...

... industry scientists. Investigators must adapt research methods to accommodate the scientific advances associated with cell therapy. Safety and efficacy of cell therapy for cardiovascular indications should be evaluated with the same degree of scientific rigor required of pharmacologic agents, and the same...

...James Shepherd; Donald G. Vidt; Elinor Miller; Susan Harris; James Blasetto Background: The safety and tolerability of rosuvastatin were assessed using data from 16,876patients who received rosuvastatin 5–40 mg in a multinational phase II/III / IIIb/IV program, representing 25,670 patient-years...

... with the median incidence per week of angina attacks and glyceryl trinitrate consumption. Safety was assessed by adverse event frequency, measurement of vital signs and laboratory parameters, and quality of life. At the final visit, the total exercise time was significantly greater relative to baseline...