... by the abundance of mitochondria. Reactive oxygen species (ROS) generated in a hypoxic heart will suppress myocardial contraction and induce cell damage and death [ 1,2 ]. At the molecular level, an increased generation of ROS will induce mitochondrial permeability transition pore (mPTP) opening, a loss...

.... Vascular and muscle NO signaling coordinate skeletal muscle and myocardial energy demand with supply and are critical for both carbohydrate and fatty acid total-body homeostasis. NO signaling in mitochondria underlies much of NO’s metabolic effect, which, at low physiologic levels, links cellular energy...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mitochondria Carnitine palmitoyltransferase Coronary artery disease Dilated...

...J. Gvozdják; A. Gvozdjáková; J. Kucharská; V. Bada The effect of the beta-adrenoceptor antagonist metipranolol given twice daily in a dose of 0.5 mg/kg body weight for 3 days on respiration, respiratory control index of mitochondria and oxidative phosphorylation was measured in the heart muscle...

... and oxidative phosphorylation (ADP/O ratio) were not affected in any group. These data illustrate that the degree of biochemical damage following reperfusion of the ischemic myocardium is determined by the degree of ischemia, and suggest that interference with ATP production by the mitochondria...

..., instructions or products referred to in the content or advertisements. Dilated cardiomyopathy Mitochondria Mitochondrial DNA mutation Pathology Single large-scale mitochondrial DNA (mtDNA) deletions are usually associated with syndromes including progressive external ophthalmoplegia (PEO...