... coronary syndromes Angina Unstable angina Clinical trials Composite endpoint Unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) comprise the three main presentations of acute coronary syndromes (ACS) [1...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Diabetes mellitus Cardiovascular disease Clinical trials The global prevalence of type 2 diabetes mellitus (T2DM) continues to skyrocket...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Prasugrel Clopidogrel Cancer Noncardiovascular deaths Clinical trials...

...; moreover, the vast majority of pertinent clinical trials do not describe dyspnea in their safety/adverse events sections in the primary publications or corresponding secondary FDA reviews. In fact, the dyspnea rates between two irreversible thienopyridines in the phase 3 TRITON trial were below 5...

.... Ticagrelor Mortality rates Acute coronary syndromes Clinical trials Controversy continues regarding the interpretation of the relatively high death rates reported in the PLATO (PLATelet Inhibition and Clinical Outcomes) trial [ 1 ], which might importantly affect the benefit inferred from the use...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ticagrelor Clopidogrel Clinical trials Monitoring Antiplatelet...

... infarction Bone marrow Clinical trials Stem cell therapy has long since been considered a promising approach for helping to repair the heart after myocardial infarction (MI) or, even better, for preventing it from deteriorating in the first place. Experimental studies investigating different kinds...

... there is a major disagreement between centrally adjudicated and site-reported events influencing the results of a major clinical trial. Fig. 1 Timing of event adjudication in TRITON. Fig. 1. Timing of event adjudication in TRITON. Recognizing that TRITON started enrolling patients late in 2004...

... and coronary heart disease. It will also discuss the ongoing clinical trials aimed at clarifying some unsolved issues of antihypertensive treatment. The objective of the International Nifedipine GITS Study Intervention as a Goal in Hypertensive Treatment was to provide information on the effects of calcium...

...Antonio M. Gotto, Jr. An abundance of clinical trial data indicates that lipid-regulating therapy reduces coronary artery disease morbidity and mortality. In patients with established coronary artery disease, lipid regulation has been shown to attenuate progression of atherosclerosis and extend...

... Myocardial infarction Angiotensin-converting enzyme Clinical trials Abstract Recent trials have shown that angiotensin-converting enzyme (ACE) inhibi­ tors can reduce mortality and the occurrence of severe left ventricular dysfunc­ tion (LVD) when started within the first day after acute myocardial...

.... Diuretics Hypertension Clinical trials Morbidity Mortality Metabolic effects Session II: Hypertension Cardiology 1994;84(suppl 2):27 35 Marvin Moser Section of Preventive Cardiology, Department of Medicine, Yale University School of Medicine, New Haven, Conn., USA Effect of Diuretics on Morbidity...

... reviews important aspects of the design and analysis of key clinical studies and assesses the impact of the results of clinical trials on clinical practice. 18 11 2008 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Clinical trials Clinical practice Angiotensin-converting enzyme inhibitors Lisinopril Assessment of Treatment with Lisinopril and Survival (ATLAS) Trials for Life: The Influence of Mortality...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Clinical trials Clinical practice Audit Marketing Cardiovascular...

...Milton Packer Clinical trial results are not readily adopted into everyday clinical practice. Despite the publication of numerous clinical studies, many findings still continue to be ignored, misunderstood or remain unknown by physicians. In clinical trials, drug dosing and timing are carefully...

...Gary S. Francis Congestive heart failure has emerged as an important public health problem world wide. It is the single most common cause for hospitalization of patients over the age of 65 years in the United States. The past decade has witnessed the completion of a number of clinical trials which...

.... Measurement Quality of life Clinical trials Heart Failure Today Symp., La Napoule 1987 Cardiology 75: suppl. 1, pp. 41-52 (1988) © 1988 S. Kargcr AG, Basel 0008-6312/88/0757-0041$2.75/0 Measurement of Quality of Life in Clinical Trials of Therapy A.E. Fletcher, C.J. Bulpitt Epidemiology Research Unit...

...Curt D. Furberg Ventricular arrhythmias are the major cause of death in patients with coronary heart disease. By suppressing the arrhythmias, antiarrhythmic agents have the theoretical potential of preventing sudden arrhythmic deaths. A large number of randomized, controlled clinical trials...

... Trials of Antiarrhythmic Therapy An Improper Answer to a Proper Question? Jacobus Lubsen Clinical Epidemiological Unit, Department of Cardiology, Erasmus University. Rotterdam, The Netherlands Key Words. Sudden cardiac death Antiarrhythmic therapy Clinical trials Secondary prevention of coronary...