... coronary syndromes Angina Unstable angina Clinical trials Composite endpoint Unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) comprise the three main presentations of acute coronary syndromes (ACS) [1...

... difference and a number of variables including weight gain, incident heart failure, duration of diabetes and polypharmacy with a variety of antidiabetic medications [ 34 ]. Notwithstanding, it is well known that identification of an empirical causal pathway within a clinical trial can be difficult [ 14...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Prasugrel Clopidogrel Cancer Noncardiovascular deaths Clinical trials...

... Ticagrelor Elinogrel Cangrelor Transfusion-related acute lung injury Clinical trials Dyspnea, or shortness of breath, is a common reason for seeking medical attention and often requires evaluation in the emergency department [ 1 ], often followed by hospital admission. In the USA, dyspnea...

.... Ticagrelor Mortality rates Acute coronary syndromes Clinical trials Controversy continues regarding the interpretation of the relatively high death rates reported in the PLATO (PLATelet Inhibition and Clinical Outcomes) trial [ 1 ], which might importantly affect the benefit inferred from the use...

... trials. In PLATO, this pattern seems to have favored the experimental drug and may require further assessment. 26 11 2011 5 1 2012 Procedures for the verification of data are intended to maintain the reliability of results of randomized clinical trials. Therefore, the censoring...

... infarction Bone marrow Clinical trials Stem cell therapy has long since been considered a promising approach for helping to repair the heart after myocardial infarction (MI) or, even better, for preventing it from deteriorating in the first place. Experimental studies investigating different kinds...

... there is a major disagreement between centrally adjudicated and site-reported events influencing the results of a major clinical trial. 14 01 2010 29 01 2010 16 3 2010 © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... and coronary heart disease. It will also discuss the ongoing clinical trials aimed at clarifying some unsolved issues of antihypertensive treatment. The objective of the International Nifedipine GITS Study Intervention as a Goal in Hypertensive Treatment was to provide information on the effects of calcium...

... Myocardial infarction Angiotensin-converting enzyme Clinical trials Abstract Recent trials have shown that angiotensin-converting enzyme (ACE) inhibi­ tors can reduce mortality and the occurrence of severe left ventricular dysfunc­ tion (LVD) when started within the first day after acute myocardial...

...Antonio M. Gotto, Jr. An abundance of clinical trial data indicates that lipid-regulating therapy reduces coronary artery disease morbidity and mortality. In patients with established coronary artery disease, lipid regulation has been shown to attenuate progression of atherosclerosis and extend...

.... Diuretics Hypertension Clinical trials Morbidity Mortality Metabolic effects Session II: Hypertension Cardiology 1994;84(suppl 2):27 35 Marvin Moser Section of Preventive Cardiology, Department of Medicine, Yale University School of Medicine, New Haven, Conn., USA Effect of Diuretics on Morbidity...

...Milton Packer Clinical trial results are not readily adopted into everyday clinical practice. Despite the publication of numerous clinical studies, many findings still continue to be ignored, misunderstood or remain unknown by physicians. In clinical trials, drug dosing and timing are carefully...

... reviews important aspects of the design and analysis of key clinical studies and assesses the impact of the results of clinical trials on clinical practice. 18 11 2008 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Clinical trials Clinical practice Angiotensin-converting enzyme inhibitors Lisinopril Assessment of Treatment with Lisinopril and Survival (ATLAS) Trials for Life: The Influence of Mortality...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Clinical trials Clinical practice Audit Marketing Cardiovascular...

...Gary S. Francis Congestive heart failure has emerged as an important public health problem world wide. It is the single most common cause for hospitalization of patients over the age of 65 years in the United States. The past decade has witnessed the completion of a number of clinical trials which...

.... Measurement Quality of life Clinical trials Heart Failure Today Symp., La Napoule 1987 Cardiology 75: suppl. 1, pp. 41-52 (1988) © 1988 S. Kargcr AG, Basel 0008-6312/88/0757-0041$2.75/0 Measurement of Quality of Life in Clinical Trials of Therapy A.E. Fletcher, C.J. Bulpitt Epidemiology Research Unit...

...Curt D. Furberg Ventricular arrhythmias are the major cause of death in patients with coronary heart disease. By suppressing the arrhythmias, antiarrhythmic agents have the theoretical potential of preventing sudden arrhythmic deaths. A large number of randomized, controlled clinical trials...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sudden cardiac death Antiarrhythmic therapy Clinical trials Secondary...