Novelty is the lifeblood of the scientific publication in general, and this includes the vast field of cardiovascular medicine in specific. In an age of big data and algorithms driving scientific discovery, it is easily forgotten that major advances in the diagnosis and treatment of heart disease are derived from the work of men and women no longer with us today but are still remembered by many of us. These men and women, in many instances, motivated us to embark on a career in cardiology. Sir Isaac Newton put it this way: “We can see further because we are standing on the shoulders of giants.” Likewise, Sir Hans Krebs wrote in the first chapter of his autobiography (Reminiscences and Reflections, 1981): “Our forebears were no fools either.”

The Journal’s new series “Icons in Cardiology” intends to reflect on major discoveries by investigators whose work in the past paved the way for the future. We hope that our new series will be both inspirational and enjoyable. As always, we invite our readers to send us their comments and suggestions.

Heinrich Taegtmeyer, Section Editor, Houston.

Dan Atar, Editor-in-Chief, Oslo.

No competing interests exist.

The authors have no funding sources to declare.

H.T. and D.A. contributed equally.

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