Introduction: The objective of this study was to evaluate the abnormal myocardial function in HFpEF patients with renal dysfunction (RD) and investigate the relationship between renal function and myocardial mechanical characteristics in patients with HFpEF. Methods: 134 patients with HFpEF and 32 control subjects were enrolled in our study. Clinical and echocardiography data were collected for offline analysis. Global work index (GWI), global constructive work (GCW), global waste work (GWW), and global work efficiency (GWE) were measured after noninvasive pressure-strain loop analysis. Univariate and multivariate analyses were used to determine the correlation between renal function and myocardial function in patients with HFpEF. Results: In comparison to control subjects, patients with HFpEF tend to have higher GWW (78 [50–115] vs. 108 [65–160] mm Hg%, p < 0.05) and lower GWE (96 [95–97] vs. 95 [92–96] %, p < 0.05), while left ventricular ejection fraction (65.5 ± 3.3 vs. 64.3 ± 4.6%, p < 0.05) was comparable between them. Besides, increased GWW (86 [58–152] vs. 125 [94–187] mm Hg%, p < 0.05) and decreased GWE (96 [93–97] vs. 94 [92–96] %, p < 0.05) were detected in patients with RD compared to those with normal renal function. An independent correlation was found between estimated glomerular filtration rate and GWW after multivariate analysis. Discussion/Conclusion: More severely impaired myocardial function was detected in HFpEF patients with RD compared to those with normal renal function. Estimated glomerular filtration rate was independently correlated to GWW in patients with HFpEF.

Heart failure with preserved ejection fraction (HFpEF) is a type of heart failure where the heart muscle is stiff and does not relax properly, causing blood to back up in the lungs and other organs. Patients with HFpEF often have other health problems, such as kidney dysfunction, which can further worsen their heart function. The purpose of this study was to examine the relationship between kidney function and heart function in patients with a type of heart failure called HFpEF. The researchers looked at data from 134 patients with HFpEF and 32 healthy control subjects. They measured different aspects of heart function using noninvasive pressure-strain loop analysis and also assessed kidney function. The study found that patients with HFpEF tended to have poorer heart function and higher waste work in the heart compared to healthy control subjects. Patients with kidney dysfunction had even worse heart function than those with normal kidney function. The study also found a correlation between kidney function and waste work in the heart. Overall, the study suggests that kidney dysfunction is associated with poorer heart function in patients with HFpEF.

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