Biplane long-axis cine MRI was performed in 51 patients 1, 13, 26, and 52 weeks after their first AMI. LV mass index (LVMI) was significantly increased 1 week after AMI (84.3 ± 16.9 vs. 68.1 ± 11.4 g/m2 controls, n = 48, p < 0.001), presumably owing to edema of the infarcted myocardium. Six months after AMI, LVMI decreased to 76.5 ± 16.4 g/m2, but had again augmented after 1 year (81.8 ± 17.3 g/m2, p < 0.05), suggesting late, compensatory left ventricular hypertrophy. In patients treated with primary percutaneous transluminal coronary angioplasty, LVMI decreased 5% over 1 year, while LVMI increased 10% in patients receiving thrombolysis (p < 0.05). In the entire population, the global increase in LVMI 1 year after AMI seemed to reflect global cavity dilatation with unchanged thickness of the vital myocardium. In conclusion, in patients receiving contemporary treatment, LV remodeling only partially complied with the classical patho-anatomical concept.

1.
van der Wall EE: Do magnetic resonance techniques contribute to the management of clinical problems? Eur Heart J 1996;17:666–673.
2.
Kramer CM, Rogers WJ, Geskin G, Power TP, Theobald TM, Hu YL, Reichek N: Usefulness of magnetic resonance imaging early after acute myocardial infarction. Am J Cardiol 1997;80:690–695.
3.
Johnson DB, Foster RE, Barilla F, Blackwell GG, Roney M, Stanley AWH, Kirk K, Orr RA, van der Geest RJ, Reiber JHC, Dell’Italia LJ, Roney M, Stanley AW Jr, Reiber JH: Angiotensin-converting enzyme inhibitor therapy affects left ventricular mass in patients with ejection fraction >40% after acute myocardial infarction. J Am Coll Cardiol 1997;29:49–54.
4.
Germain P, Roul G, Coulbois PM, Baruthio J, Mossard JM, Bareiss P, Sacrez A: Comparison between abnormalities in segmental endocardial motion and abnormalities in segmental wall thickening after anterior myocardial infarction. Eur Heart J 1996;17:1350–1361.
5.
St. John Sutton M, Pfeffer MA, Plappert T, Rouleau J-L, Moyé LA, Dagenais GR, Lamas GA, Klein M, for the SAVE Investigators: Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril. Circulation 1994;89:68–75.
6.
Mitchell GF, Lamas GA, Vaughan DE, Pfeffer MA: Left ventricular remodeling in the year after first anterior myocardial infarction: A quantitative analysis of contractile segment lengths and ventricular shape. J Am Coll Cardiol 1992;19:1136–1144.
7.
Bonaduce D, Petretta M, Morgano G, Villari B, Bianchi V, Conforti G, Salemme L, Themistoclakis S, Pulcino A: Left ventricular remodelling in the year after myocardial infarction: An echocardiographic , haemodynamic, and radionuclide angiographic study. Coron Artery Dis 1994;5:155–162.
8.
Darasz KH, Bayliss J, Underwood SR, Keegan J, Poole-Wilson PA, Sutton GC: Left ventricular volume in thrombolysed patients with acute myocardial infarction: The effect of captopril and xamoterol. Int J Cardiol 1995;51:137–142.
9.
Konermann M, Sanner BM, Horstmann E, Grotz J, Laschewski F, Josephs W, Odenthal HJ, Sturm A: Changes of the left ventricle after myocardial infarction – Estimation with cine magnetic resonance imaging during the first six months. Clin Cardiol 1997;20:201–212.
10.
Konermann M, Altmann C, Laschewski F, Josephs W, Odenthal HJ, Horstmann E, Sanner B: Influence of tissue affinity of angiotensin-converting enzyme inhibitors on left ventricular remodeling after myocardial infarction. Clin Cardiol 1998;21:277–285.
11.
Pfeffer JM, Pfeffer MA, Fletscher PJ, Braunwald E: Progressive ventricular remodeling in rats with myocardial infarction. Am J Physiol 1991;260:H1406–H1414.
12.
Anversa P, Olivetti G, Capasso JM: Cellular basis of ventricular remodeling after myocardial infarction. Am J Cardiol 1991;68:7D–16D.
13.
Garot P, Juliard J-M, Benamer H, Steg PG: Are the results of primary percutaneous transluminal coronary angioplasty for acute myocardial infarction different during the ‘off’ hours? Am J Cardiol 1997;79:1527–1529.
14.
Hansen H-HT, Thuesen L, Rasmussen K, Andersen HR, Vesterlund T, Villadsen AB, Schroeder AP, Husted SE, Nielsen TT: Percutaneous transluminal coronary angioplasty versus thrombolysis in acute myocardial infarction: A prospective, matched, controlled study. Scand Cardiovasc J 2000;34:365–370.
15.
Madsen JK, Grande P, Saunamaki K, Thayssen P, Eriksen U, Rasmussen K, Haunsø S, Nielsen TT, Haghfelt T, Fritz-Hansen P, Hjelms E, Paulsen PK, Alstrup P, Arendrup H, Niebuhr-Jøgensen U: Danish multicenter randomised study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. Circulation 1997;96:748–755.
16.
Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, Silverman NH, Tajik AJ: Recommandations for quantification of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358–367.
17.
Du Bois D, Du Bois EF: A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916;17:863–871.
18.
Matheijssen NAA, de Roos A, Doornbos J, Reiber JHC, Waldman G-J, van der Wall EE: Left ventricular wall motion analysis in patients with acute myocardial infarction using magnetic resonance imaging. Magn Reson Imaging 1993;11:485–492.
19.
Hollis S: Analysis of method comparison studies. Ann Clin Biochem 1996;33:1–4.
20.
Pfeffer JM: Progressive ventricular dilatation in experimental myocardial infarction and its attenuation by angiotensin-converting enzyme inhibition. Am J Cardiol 1991;68:17D–25D.
21.
Kramer CM, Lima JA, Reichek N, Ferrari VA, Llaneras MR, Palmon LC, Yeh IT, Tallant B, Axel L: Regional differences in function within noninfarcted myocardium during left ventricular remodeling. Circulation 1993;88:1279–1288.
22.
Been M, Smith MA, Ridgway JP, Douglas RHB, de Bono DP, Best JJK, Muir AL: Serial changes in the T1 magnetic relaxation parameter after myocardial infarction in man. Br Heart J 1988;59:1–8.
23.
Higgins CB, Herfkens R, Lipton MJ, Sievers R, Sheldon P, Kaufman L, Crooks LE: Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: Alterations in magnetic relaxation times. Am J Cardiol 1983;52:184–188.
24.
Krauss XH, van der Wall EE, van der Laarse A, Doornbos J, de Roos A, Matheijssen NA, van Dijkman PR, van Voorthuisen AE, Bruschke AV: Follow-up of regional myocardial T2 relaxation times in patients with myocardial infarction evaluated with magnetic resonance imaging. Eur J Radiol 1990;11:110–119.
25.
Scholz TD, Martins JB, Skorton DJ: NMR relaxation times in acute myocardial infarction: Relative influences of changes in tissue water and fat content. Magn Reson Med 1992;23:89–95.
26.
Beltrami CA, Finati N, Rocco M, Feruglio GA, Puricelli C, Cigola E, Quaini F, Sonnenblick EH, Olivetti G, Anversa P: Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 1994;89:151–163.
27.
Rumberger JA, Behrenbeck T, Breen JR, Reed JE, Gersh BJ: Nonparallel changes in global left ventricular chamber volume and muscle mass during the first year after transmural myocardial infarction in humans. J Am Coll Cardiol 1993;21:673–682.
28.
Konermann M, Grotz J, Altmann C, Laschewski F, Josephs W, Hotzinger H: Left ventricular dimensions and functions in the acute and chronic phase after myocardial infarct – Comparison of cine-magnetic resonance tomography, angiocardiography, 2D-echocardiography and technetium ventricular scintigraphy. Z Kardiol 1992;81:610–618.
29.
Gaudron P, Eilles C, Kugler I, Ertl G: Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation 1993;87:755–763.
30.
Hirose K, Reed JE, Rumberger JA: Serial changes in regional right ventricular free wall and left ventricular septal wall lengths during the first 4 to 5 years after index anterior wall myocardial infarction. J Am Coll Cardiol 1995;26:394–400.
31.
Nixdorff U, Erbel R, Pop T, Rupprecht H-J, Henrichs K-J, Mörchen S, Meyer J: Long-term follow-up of global and regional left ventricular function by two-dimensional echocardiography after thrombolytic therapy in acute myocardial infarction. Cardiology 1993;41:31–47.
32.
Kramer CM, Rogers WJ, Theobald TM, Power TP, Geskin G, Reichek N: Dissociation between changes in intramyocardial function and left ventricular volumes in the eight weeks after first anterior myocardial infarction. J Am Coll Cardiol 1997;30:1625–1632.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.