Two types of genuine alcoholic cardiomyopathies can produce congestive heart failure, an acute fulminate hyperkinetic type with high cardiac output and a hypokinetic type with a low cardiac output, both of which respond to thiamine. When the chronic alcoholic develops a dilated cardiomyopathy with congestive heart failure without a history of significant malnutrition, then they do not respond to thiamine. This may be explained by a study in which mice given a myotropic virus plus alcohol developed more frequent and severe viral cardiomyopathies than those not fed alcohol. This suggests that a chronic dilated cardiomyopathy in an alcoholic may not be the direct result of the alcohol but secondary to a viral myocarditis. This suggests that the preferred terminology for a dilated cardiomyopathy in an alcoholic who does not respond to thiamine and good nutrition should simply be a dilated cardiomyopathy in an alcoholic. We should assume that the cardiomyopathy is possibly of viral etiology.

1.
Ahmed SS, Levinson GE, Regan TJ: Altered systolic time intervals with low doses of ethanol in man. Circulation 1971;43–44(suppl II):119.
2.
Child JS, Kovick RB, Levisman JA, Pearce ML: Cardiac effects of acute ethanol ingestion unmasked by autonomic blockade. Circulation 1979;59:120–125.
3.
Gould L, Reddy CVR, Goswami K, Venkataraman K, Gomprecht RF: Cardiac effects of two cocktails in normal man. Chest 1973;63:943–947.
4.
Delgado CE, Fortuin NJ, Ross RS: Acute effects of low doses of alcohol on left ventricular function by echocardiography. Circulation 1975;51:535–540.
5.
Conway N: Haemodynamic effects of ethyl alcohol in patients with coronary heart disease. Br Heart J 1968;30:638–644.
6.
Inasaka T, Sugimoto T, Kaseno K, Uraoka T, Sato K, Ikeda T: Effects of ethanol on the responses of STI to exercise: A study in the normal subjects. CV Sound Bull 1974, p 373.
7.
Gould L: Hemodynamic effects of ethanol in patients with cardiac disease (abstract). JAMA 1972;222:1331.
8.
Greenberg BH: Acute effects of alcohol in patients with congestive heart failure. Ann Intern Med 1982;97:171–175.
9.
Gould L, Zahir M, Shariff M, DiLieto M: Cardiac hemodynamics in alcoholic heart disease. Ann Intern Med 1969;71:543–553.
10.
Slany J: Ergometric studies in chronic alcoholics. JAMA 1973;223:836.
11.
Spodick DH, Pigott VM, Chirife R: Preclinical cardiac malfunction in chronic alcoholism. N Engl M Med 1972;287:677–680.
12.
Ettinger PO, Wu CF, DelaCruz C Jr, Weisse AB, Ahmed SS, Regan TJ: Arrhythmias and the ‘holiday heart’: Alcohol associated cardiac rhythm disorders. Am Heart J 1978;95:555–562.
13.
Priest RG, Binns JK, Kitchin AH: Electrocardiogram in alcoholism and accompanying physical disease. Br Med J 1966;i:1453–1454.
14.
Ettinger PO, Lyons MM, Khan MI, Jesrani MU, Regan TJ: Ventricular conduction and Purkinje cell alterations in experimental alcoholism (abstract). Am J Cardiol 1970;26:631.
15.
Tofler DB, Saker RM, Rollo KA, Burvill MJ, Stenhouse N: Electrocardiogram of the social drinker in Perth, Western Australia. Br Heart J 1969;31:306–312.
16.
Burch GE, Walsh JJ: Cardiac insufficiency in chronic alcoholism. Am J Cardiol 1960;6:864–874.
17.
Aalsmeer WC, Wenckebach KF: The heart and circulatory system in beriberi. Am Heart J 1929;4:630.
18.
Attas M, Hanley HG, Stultz D, Jones MR, McAllister RG: Fulminant beriberi heart disease with lactic acidosis. Circulation 1978;58:566–571.
19.
King JF, Easton R, Dunn M: Acute pernicious beriberi heart disease. Chest 1972;61:512–517.
20.
Kawai C, Wakabayashi A, Hirose K, Yui Y, Itokawa Y: Cardiomyopathies of miscellaneous origin. World Congress Tokyo, 1978, 0841.
21.
Nishi S, Shinyashiki T, Uchimura S, Tanaka H, Katanazako H, Okura H, Kanehisa T: Electron microscopic observations on cardiomyopathy in thiamine deficient mice. World Congress Tokyo, 1978, 0842.
22.
Constant J: Solving nomenclature problems in cardiology: II. Updating terminology in clinical cardiology. Cardiology 1995;86:361–364.
23.
Baron JH, Oliver LC: Fulminating beriberi. Lancet 1958;i:354–356.
24.
Herrell WE: Beer drinkers’ disease. Clin Med 1967;74:15.
25.
Fernandez-Sola J, Estruch R, Grau JM, Pare JC, Rubin E, Urbano-Marquez A: The relation of alcoholic myopathy to cardiomyopathy. Ann Intern Med 1994;120:529–536.
26.
Askanas A, Udoshi M, Sadjadi SA: The heart in chronic alcoholism: A noninvasie study. Am Heart J 1980;99:9–16.
27.
Ballas M, Zoneraich S, Yunis M, Zoneraich O, Rosner F: Noninvasive cardiac evaluation in chronic alcoholic patients with alcohol withdrawal syndrome. Chest 1982;82:148–153.
28.
Tobin JR, Driscoll JF, Lim MT, Sutton GC, Szanto PB, Gunnar RM: Primary myocardial disease and alcoholism. Circulation 1967;35:754–764.
29.
Alexander CS: Idiopathic heart disease: Electron microscopic examination of myocardial biopsy specimens in alcoholic heart disease. Am J Med: 1966;41:229–234.
30.
Bulloch RT, Pearce MB, Murphy M, Jenkins BJ, Davis JL: Myocardial lesions in idiopathic and alcoholic cardiomyopathy. Am J Cardiol 1972;29:15–25.
31.
Burin E: Cardiovascular effects of alcohol. Pharmacol Biochem Behav 1980;13(suppl 1):37–40.
32.
McDonald CD, Burch GE, Walsh JJ: Alcoholic cardiomyopathy managed with prolonged bed rest. Ann Intern Med 1971;74:681–691.
33.
Regan TJ, Levinson GE, Oldewurtel HA, Frank MJ, Weisse AB, Moschos CB: Ventricular function in noncardiacs with alcoholic fatty liver: Role of ethanol in the production of cardiomyopathy. J Clin Invest 1969;48:397–407.
34.
Schwartz L, Sample KA, Wigle ED: Severe alcoholic cardiomyopathy reversed with abstention from alcohol. Am J Cardiol 1975;36:963–966.
35.
Miller H, Abelman WH: Effects of dietary ethanol upon experimental trypanasomal myocarditis. Proc Soc Exp Biol 1967;126:193–198.
36.
Hibbs RG, Ferrans VJ, Black WC: Alcoholic cardiomyopathy. An electron microscopic study. Am Heart J 1965;69:766–769.
37.
Pauschinger M, Preis S, Triesch A, Doerner A, Schultheil HG: Detection of entoviral RNA in endomyocardial biopsies in patients having chronic myocarditis. Circulation 1994;90:1174.
38.
Levi GF, Prote C, Quadri A, Ratti S: Coxsackie virus disease and cardiomyopathy. Am Heart J 1977;93:419–421.
39.
Saivani G, Dekate MP, Rao CP: Heart disease caused by Coxsackie virus B infection. Br Heart J 1975;37:819–823.
40.
Huber SA, Lodge PA: Coxsackie virus B-3 myocarditis in mice. Am J Pathol 1984;116:21–29.
41.
Morin Y, Roy PE, Mohiuddin SM, Taskar PK: The influence of alcohol on viral and isoproterenol cardiomyopathy. Cardiovasc Res 1969;3:363–368.
42.
Regan TJ, Koroxenidis G, Moschos CB: The acute metabolic and hemodynamic responses of the left ventricle to ethanol. J Clin Invest 1966;45:270–280.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.