To derive better criteria for the noninvasive localization of coronary artery disease, a 12-lead computer-averaged rest and exercise electrocardiogram was examined in 44 selected patients (34 men, 10 women) with single-vessel disease who had an exercise test positive for ischemia by established criteria. Left anterior descending disease was characterized by S-T segment elevation ( > 0.05 mV) in lead VI [sensitivity (S) 71%, specificity (Sp) 100%], a T wave amplitude increase in VI (S 88%, Sp 73%) and a leftward shift or no change in mean frontal plane QRS axis (AQRS; S 92%, Sp 93%). Patients with circumflex or right coronary artery disease had no S-T segment elevation in VI and a rightward shift in the mean frontal plane AQRS.

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