Mitral valve (MV) specimens obtained at operation from 50 patients with ostium secundum atrial septal defect and associated MV dysfunction were studied macro- and microscopically to evaluate the structural lesions. The functional abnormalities in these patients were isolated mitral stenosis, isolated mitral regurgitation, mitral valve prolapse or mitral stenosis with regurgitation. Post-inflammatory lesions were commonly found in those with mitral stenosis who had a past history of rheumatic fever. Patients with mitral valve prolapse had either post-inflammatory lesions or lesions attributable to hae-modynamic stress but different from the extensive lesions seen in floppy MV syndrome.

Keywords:
Congenital heart disease, Atrial septal defect, Mitral valve, Mitral valve prolapse, Rheumatic fever
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© 1993 S. Karger AG, Basel
1993
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