This is a prospective multicenter registry of atrial fibrillation (AF) ablation with the Ablation Index (AI) technology, which has been introduced as a marker predicting ablation lesion depth. The index incorporates the main parameters of radiofrequency point-by-point ablation: power, contact force, and time of ablation. The AI is calculated for every operator depending on personal skills, and there are no strict indications on the range of the parameter considering its safety and efficacy during pulmonary vein isolation. The registry aims to evaluate AI values used in different centers by different operators and to evaluate the optimal limits associated with better acute and long-term AF ablation results.

1.
Zulkifly
H
,
Lip
GY
,
Lane
DA
.
Epidemiology of atrial fibrillation
.
Int J Clin Pract
.
2018
Mar
;
72
(
3
):
e13070
.
[PubMed]
1368-5031
2.
Global Burden of Disease Collaborative Network
. (
2016
) Global Burden of Disease Study 2016 (GBD 2016) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2017. Accessed 2018-04-20. Available from http://ghdx.healthdata.org/gbd-results-tool
3.
Chugh
SS
,
Havmoeller
R
,
Narayanan
K
,
Singh
D
,
Rienstra
M
,
Benjamin
EJ
, et al
Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study
.
Circulation
.
2014
Feb
;
129
(
8
):
837
47
.
[PubMed]
0009-7322
4.
Odutayo
A
,
Wong
CX
,
Hsiao
AJ
,
Hopewell
S
,
Altman
DG
,
Emdin
CA
.
Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis
.
BMJ
.
2016
Sep
;
354
:
i4482
.
[PubMed]
0959-8138
5.
Sulimov
VA
,
Golicyn
SP
,
Panchenko
EP
,
Popov
SV
,
Revishvili
ASh
,
Shubik
YuV
, et al
Diagnosis and treatment of atrial fibrillation.
Russ J Cardiol.
2013
;18(4)S3:5-100. doi: .
6.
Kirchhof
P
,
Benussi
S
,
Kotecha
D
,
Ahlsson
A
,
Atar
D
,
Casadei
B
, et al;
ESC Scientific Document Group
.
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
.
Eur Heart J
.
2016
Oct
;
37
(
38
):
2893
962
.
[PubMed]
0195-668X
7.
January
CT
,
Wann
LS
,
Alpert
JS
,
Calkins
H
,
Cigarroa
JE
,
Cleveland
JC
 Jr
, et al;
ACC/AHA Task Force Members
.
2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society
.
Circulation
.
2014
Dec
;
130
(
23
):
e199
267
.
[PubMed]
0009-7322
8.
Calkins
H
,
Hindricks
G
,
Cappato
R
,
Kim
YH
,
Saad
EB
,
Aguinaga
L
, et al
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
.
Heart Rhythm
.
2017
Oct
;
14
(
10
):
e275
444
.
[PubMed]
1547-5271
9.
Hussein
A
,
Das
M
,
Riva
S
,
Morgan
M
,
Ronayne
C
,
Sahni
A
, et al
Use of ablation index-guided ablation results in high rates of durable pulmonary vein isolation and freedom from arrhythmia in persistent atrial fibrillation patients
.
Circ Arrhythm Electrophysiol
.
2018
Sep
;
11
(
9
):
e006576
.
[PubMed]
1941-3149
10.
Phlips
T
,
Taghji
P
,
El Haddad
M
,
Wolf
M
,
Knecht
S
,
Vandekerckhove
Y
, et al
Improving procedural and one-year outcome after contact force-guided pulmonary vein isolation: the role of interlesion distance, ablation index, and contact force variability in the ‘CLOSE’-protocol. Europace.
2018
Nov
1
;20(FI_3):419-427. doi:
11.
Lee
SR
,
Choi
EK
,
Lee
EJ
,
Choe
WS
,
Cha
MJ
,
Oh
S
.
Efficacy of the optimal ablation index-targeted strategy for pulmonary vein isolation in patients with atrial fibrillation: the OPTIMUM study results
.
J Interv Card Electrophysiol
.
2019
Aug
;
55
(
2
):
171
81
.
[PubMed]
1383-875X
12.
Arbelo
E
,
Brugada
J
,
Blomström-Lundqvist
C
,
Laroche
C
,
Kautzner
J
,
Pokushalov
E
, et al;
on the behalf of the ESC-EHRA Atrial Fibrillation Ablation Long-term Registry Investigators
.
Contemporary management of patients undergoing atrial fibrillation ablation: in-hospital and 1-year follow-up findings from the ESC-EHRA atrial fibrillation ablation long-term registry
.
Eur Heart J
.
2017
May
;
38
(
17
):
1303
16
.
[PubMed]
0195-668X
13.
Mikhailov
EN
,
Gasymova
NZ
,
Bayramova
SA
,
Kharats
VE
,
Kachalkova
ON
,
Dmitriyev
AY
, et al
Clinical chracteristics of patients and results of catheter ablation in atrial fibrillation in Russia: subanalysis of the European Registry 2012-2016
.
Russian Journal of Cardiology.
2018
;
23
(
7
):
7
15
.
14.
Hindricks
G
,
Camm
J
,
Merkely
B
,
Raatikainen
P
,
Arnar
D
.
The EHRA White Book
.
2017
. The current status of cardiac electrophysiology in ESC member countries. Available from URL https://www.escardio.org/static_file/Escardio/Subspecialty/EHRA/Publications/Documents/2017/ehra-white-book-2017.pdf
15.
Mansour
M
,
Karst
E
,
Heist
EK
,
Dalal
N
,
Wasfy
JH
,
Packer
DL
, et al
The Impact of First Procedure Success Rate on the Economics of Atrial Fibrillation Ablation
.
JACC Clin Electrophysiol
.
2017
Feb
;
3
(
2
):
129
38
.
[PubMed]
2405-5018
16.
Kimura
M
,
Sasaki
S
,
Owada
S
,
Horiuchi
D
,
Sasaki
K
,
Itoh
T
, et al
Comparison of lesion formation between contact force-guided and non-guided circumferential pulmonary vein isolation: a prospective, randomized study
.
Heart Rhythm
.
2014
Jun
;
11
(
6
):
984
91
.
[PubMed]
1547-5271
17.
Andrade
JG
,
Monir
G
,
Pollak
SJ
,
Khairy
P
,
Dubuc
M
,
Roy
D
, et al
Pulmonary vein isolation using “contact force” ablation: the effect on dormant conduction and long-term freedom from recurrent atrial fibrillation—a prospective study
.
Heart Rhythm
.
2014
Nov
;
11
(
11
):
1919
24
.
[PubMed]
1547-5271
18.
Pranata
R
,
Vania
R
,
Huang
I
.
Ablation-index guided versus conventional contact-force guided ablation in pulmonary vein isolation - Systematic review and meta-analysis
.
Indian Pacing Electrophysiol J
.
2019
Jul - Aug
;
19
(
4
):
155
60
.
[PubMed]
0972-6292
19.
Nakagawa
H
,
Ikeda
A
,
Govari
A
,
Papaioannou
T
,
Constantine
G
,
Bar-Tal
M
, et al
Prospective study using a new formula incorporating contact force, radiofrequency power and application time (forcepower-time index) for quantifying lesion formation to guide long continuous atrial lesions in the beating canine heart
.
Circulation
.
2013
;
128
:
A12104
. 0009-7322
20.
Das
M
,
Loveday
JJ
,
Wynn
GJ
,
Gomes
S
,
Saeed
Y
,
Bonnett
LJ
, et al
Ablation index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values
.
Europace
.
2017
May
;
19
(
5
):
775
83
.
[PubMed]
1532-2092
21.
El Haddad
M
,
Taghji
P
,
Phlips
T
,
Wolf
M
,
Demolder
A
,
Choudhury
R
, et al
Determinants of acute and late pulmonary vein reconnection in contact force guided pulmonary vein isolation
.
Circ Arrhythm Electrophysiol
.
2017
Apr
;
10
(
4
):
e004867
.
[PubMed]
1941-3149
22.
Taghji
P
,
El Haddad
M
,
Phlips
T
,
Wolf
M
,
Knecht
S
,
Vandekerckhove
Y
, et al
Evaluation of a strategy aiming to enclose the pulmonary veins with contiguous and optimized radiofrequency lesions in paroxysmal atrial fibrillation: a pilot study
.
JACC Clin Electrophysiol
.
2018
Jan
;
4
(
1
):
99
108
.
[PubMed]
2405-5018
23.
Solimene
F
,
Lepillier
A
,
De Ruvo
E
,
Scaglione
M
,
Anselmino
M
,
Sebag
FA
, et al
Reproducibility of acute pulmonary vein isolation guided by the ablation index
.
Pacing Clin Electrophysiol
.
2019
Jul
;
42
(
7
):
874
81
.
[PubMed]
0147-8389
24.
Duytschaever
M
,
Vijgen
J
,
De Potter
T
,
Van Herendael
H
,
Kobza
R
,
Knechtet
S
, al. Reproducibility and acute efficacy of a standardized approach to isolate the pulmonary veins: results from multicenter VISTAX study. European Heart Journal, Volume 39, Issue suppl_1,
August
2018
, ehy566.P6227. doi:
25.
Cappato
R
,
Calkins
H
,
Chen
SA
,
Davies
W
,
Iesaka
Y
,
Kalman
J
, et al
Worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation
.
Circulation
.
2005
Mar
;
111
(
9
):
1100
5
.
[PubMed]
0009-7322
26.
Sairaku
A
,
Yoshida
Y
,
Nakano
Y
,
Maeda
M
,
Hirayama
H
,
Hashimoto
H
, et al
Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation
.
Europace
.
2016
Sep
;
18
(
9
):
1352
6
.
[PubMed]
1099-5129
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.