Carcinoid syndrome causes a rare form of acquired valvular heart disease which typically occurs in the setting of liver metastases. In carcinoid-induced valvular heart disease, the tricuspid valve is almost universally affected; left-sided valve disease occurs infrequently in affected patients. Herein, we report 2 cases of carcinoid-induced valvular heart disease; one case had no evidence of tricuspid valve involvement despite severe involvement of all other valves, while the other case was without severe tricuspid valve involvement.

1.
Modlin IM, Sandor A: An analysis of 8,305 cases of carcinoid tumors. Cancer 1997;79:813-829.
2.
Pellikka PA, Tajik AJ, Khandheria BK, et al: Carcinoid heart disease: clinical and echocardiographic spectrum in 74 patients. Circulation 1993;87:1188-1196.
3.
Robiolio PA, Rigolin VH, Wilson JS, et al: Carcinoid heart disease: correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation 1995;92:790-795.
4.
Moller JE, Pellikka PA, Bernheim AM, Schaff HV, Rubin J, Connolly HM: Prognosis of carcinoid heart disease: analysis of 200 cases over two decades. Circulation 2005;112:3320-3327.
5.
Simula DV, Edwards WD, Tazelaar HD, Connolly HM, Schaff HV: Surgical pathology of carcinoid heart disease: a study of 139 valves from 75 patients spanning 20 years. Mayo Clin Proc 2002;77:139-147.
6.
McGuire MR, Pugh DM, Dunn MI: Carcinoid heart disease: restrictive cardiomyopathy as a late complication. J Kans Med Soc 1978;79:661-662, 665.
7.
Ross EM, Roberts WC: The carcinoid syndrome: comparison of 21 necropsy subjects with carcinoid heart disease to 15 necropsy subjects without carcinoid heart disease. Am J Med 1985;79:339-354.
8.
Connolly HM, Schaff HV, Mullany CJ, Rubin J, Abel MD, Pellikka PA: Surgical management of left-sided carcinoid heart disease. Circulation 2001;104:I36-I40.
9.
Marupakula V, Vinales KL, Najib MQ, Lanza LA, Lee HR, Chaliki HP: Occurrence of left-sided heart valve involvement before right-sided heart valve involvement in carcinoid heart disease. Eur J Echocardiogr 2011;12:E18.
10.
Bhattacharyya S, Jagroop A, Gujral DM, et al: Circulating plasma and platelet 5-hydroxytryptamine in carcinoid heart disease: a pilot study. J Heart Valve Dis 2013;22:400-407.
11.
Denney WD, Kemp WE Jr, Anthony LB, Oates JA, Byrd BF 3rd: Echocardiographic and biochemical evaluation of the development and progression of carcinoid heart disease. J Am Coll Cardiol 1998;32:1017-1022.
12.
Moller JE, Connolly HM, Rubin J, Seward JB, Modesto K, Pellikka PA: Factors associated with progression of carcinoid heart disease. N Engl J Med 2003;348:1005-1015.
13.
Connolly HM, Nishimura RA, Smith HC, Pellikka PA, Mullany CJ, Kvols LK: Outcome of cardiac surgery for carcinoid heart disease. J Am Coll Cardiol 1995;25:410-416.
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