Objectives: To assess the prognostic value of coexisting coronary artery disease (CAD), Markis class, and ectasia ratio for major adverse cardiovascular events in patients with coronary artery ectasia (CAE). Methods: A total of 512 consecutive patients with angiographically proven CAE were enrolled. Coronary ectasia extent was graded using the Markis class, and ectasia severity was assessed based on the ectasia ratio. Patients were followed up for a median of 34.6 months. Results: In the current study, 76 cases had isolated CAE, while the remaining 436 cases had coexisting CAD (mixture CAE). Males (84.4%) were predominantly affected, and the right coronary artery (55.1%) was most commonly involved. During follow-up, 86 overall major adverse cardiovascular events were diagnosed. Kaplan-Meier analysis failed to reveal any differences between isolated and mixture CAE in both cumulative and event-free survival analyses (p = 0.429 and p = 0.277, respectively). Moreover, when patients were divided into 4 groups according to Markis class (type I-IV) or 2 groups based on the ectasia ratio (1.5-2.0 and >2.0), there was no significant difference in survival outcomes among the groups (p > 0.05). Conclusions: In this follow-up study with a relatively large sample, the survival rate of patients with CAE appeared to be independent of coexisting CAD and ectasia extent and severity.

Swaye PS, Fisher LD, Litwin P, Vignola PA, Judkins MP, Kemp HG, Mudd JG, Gosselin AJ: Aneurysmal coronary artery disease. Circulation 1983;67:134-138.
Pinar Bermudez E, Lopez Palop R, Lozano Martinez-Luengas I, Cortes Sanchez R, Carrillo Saez P, Rodriguez Carreras R, Pico Aracil F, Valdes Chavarri M: Coronary ectasia: prevalence, and clinical and angiographic characteristics. Rev Esp Cardiol 2003;56:473-479.
Boles U, Zhao Y, David S, Eriksson P, Henein MY: Pure coronary ectasia differs from atherosclerosis: morphological and risk factors analysis. Int J Cardiol 2012;155:321-323.
Li JJ, He JG, Nan JL, He ZX, Zhu CG, Li J: Is systemic inflammation responsible for coronary artery ectasia? Int J Cardiol 2008;130:e69-e70.
Brunetti ND, Salvemini G, Cuculo A, Ruggiero A, De Gennaro L, Gaglione A, Di Biase M: Coronary artery ectasia is related to coronary slow flow and inflammatory activation. Atherosclerosis 2014;233:636-640.
Gunes Y, Boztosun B, Yildiz A, Metin Esen A, Saglam M, Bulut M, Karapinar H, Kirma C: Clinical profile and outcome of coronary artery ectasia. Heart 2006;92:1159-1160.
Saglam M, Karakaya O, Barutcu I, Esen AM, Turkmen M, Kargin R, Esen O, Ozdemir N, Kaymaz C: Identifying cardiovascular risk factors in a patient population with coronary artery ectasia. Angiology 2007;58:698-703.
Aboeata AS, Sontineni SP, Alla VM, Esterbrooks DJ: Coronary artery ectasia: current concepts and interventions. Front Biosci (Elite Ed) 2012;4:300-310.
Valente S, Lazzeri C, Giglioli C, Sani F, Romano SM, Margheri M, Comeglio M, Gensini GF: Clinical expression of coronary artery ectasia. J Cardiovasc Med (Hagerstown) 2007;8:815-820.
Bitigen A, Tanalp AC, Elonu OH, Karavelioglu Y, Ozdemir N: Mean platelet volume in patients with isolated coronary artery ectasia. J Thromb Thrombolysis 2007;24:99-103.
Zografos TA, Korovesis S, Giazitzoglou E, Kokladi M, Venetsanakos I, Paxinos G, Fragakis N, Katritsis DG: Clinical and angiographic characteristics of patients with coronary artery ectasia. Int J Cardiol 2013;167:1536-1541.
Sayin T, Doven O, Berkalp B, Akyurek O, Gulec S, Oral D: Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J Cardiol 2001;78:143-149.
Demopoulos VP, Olympios CD, Fakiolas CN, Pissimissis EG, Economides NM, Adamopoulou E, Foussas SG, Cokkinos DV: The natural history of aneurysmal coronary artery disease. Heart 1997;78:136-141.
Sengul C, Cevik C, Ozveren O, Sunbul A, Kilicarslan F, Oduncu V, Can M, Semiz E, Dindar I: Assessment of atrial conduction time in patients with coronary artery ectasia. Pacing Clin Electrophysiol 2011;34:1468-1474.
Lee AY, Huang CL, Shyu MY: Ventricular fibrillation during coronary angiography in a patient with left dominant coronary artery ectasia. Exp Clin Cardiol 2012;17:79-80.
Ceyhan K, Koc F, Ozdemir K, Celik A, Altunkas F, Karayakali M, Kadi H, Ozturk A, Kaya MG: Coronary ectasia is associated with impaired left ventricular myocardial performance in patients without significant coronary artery stenosis. Med Princ Pract 2012;21:139-144.
Kosar F, Acikgoz N, Sahin I, Topal E, Aksoy Y, Cehreli S: Effect of ectasia size or the ectasia ratio on the thrombosis in myocardial infarction frame count in patients with isolated coronary artery ectasia. Heart Vessels 2005;20:199-202.
Campeau L: Letter: Grading of angina pectoris. Circulation 1976;54:522-523.
Hamm CW, Braunwald E: A classification of unstable angina revisited. Circulation 2000;102:118-122.
Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R: Clinical significance of coronary arterial ectasia. Am J Cardiol 1976;37:217-222.
Swanton RH, Thomas ML, Coltart DJ, Jenkins BS, Webb-Peploe MM, Williams BT: Coronary artery ectasia - a variant of occlusive coronary arteriosclerosis. Br Heart J 1978;40:393-400.
Ismail AM, Rayan M, Adel A, Demerdash S, Atef M, Abdallah M, Nammas W: Prevalence and pattern of abnormal myocardial perfusion in patients with isolated coronary artery ectasia: study by 99m Tc-sestamibi radionuclide scintigraphy. Int J Cardiovasc Imaging 2014;30:425-430.
Kosar F, Acikgoz N, Sahin I, Topal E, Gunen H, Ermis N, Cehreli S: Effects of co-existence of coronary stenosis and the extent of coronary ectasia on the TIMI frame count in patients with coronary artery ectasia. Int Heart J 2005;46:211-218.
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