... for treatment of disease. In the present study, we also observed that TLR4 activated p38MAPK. As the pathology of COPD mediated by microorganisms, the pathogenic material (LPS) binds with TLR4 and phosphorylate and activate the MAPK pathway [ 13 ]. In present study, we observed when the cells were...

.... Furthermore, the incubation of cells with CdCl2 significantly increased the level of phosphorylated p38MAPK and significantly decreased the phosphorylation of ERK1/2 in a concentration-dependent manner. Additionally, the inhibition of the phosphorylation of p38 MAPK by SB202190 protected MG63 cells from Cd...

... reduced doxorubicin induced cardiomyocyte apoptosis with the attenuated ROS production. SIRT1 also reduced cell apoptosis by inhibition of p38MAPK phosphorylation and caspase-3 activation. The SIRT1 agonist resveratrol was able to prevent doxorubicin-induced heart function loss. Moreover, the SIRT1...

... the HOE-694-sensitive pH i recovery rate and p-Erk1/2 and p90 RSK abundance. These parameters were reduced by PD-98059, a Mek inhibitor (1 µM). Chronic high glucose treatment also increased the HOE-694-sensitive pH i recovery rate and p-p38MAPK abundance. Both parameters were reduced by SB-203580...

...-induced actin polymerization and reduction of cell adhesion, indicating that the cytoskeleton reorganization decreased the cellular adhesion ability. Furthermore, the ATP depletion markedly increased the levels of p38MAPK and HSP27 phosphorylation with enhanced translocation of phosphorylated HSP27 from...