... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Osteosarcoma MicroRNAs miR-423-5p STMN1 Osteosarcoma is the most prevalent malignant tumor of bone and is usually observed in young adults and adolescents [ 1-5...

...Yu-Qing Huang; Jie Li; Cheng Huang; Ying-Qing Feng Background/Aims: Atherosclerosis is a serious disease that increases the risk of myocardial infarction and ischemic stroke. Previous studies have demonstrated that microRNA (miR)-29c could play significant roles in atherosclerosis via regulating...

...Nan Li; Chuan-Chuan Nan; Xue-Yun Zhong; Jun-Quan Weng; Hai-Dong Fan; Hai-Peng Sun; Su Tang; Lei Shi; Sheng-Xing Huang Background/Aims: Emerging evidence suggests that the propagation of oral squamous cell carcinoma (OSCC) is influenced by the abnormal expression of microRNAs (miRNAs). This study...

...Zhen Zhang; Chaoqi Zhang; Feng Li; Bin Zhang; Yi Zhang MicroRNAs (miRNAs) have emerged as crucial regulators of T lymphocyte survival, differentiation and function, all of which are key factors impacting the outcome of adoptive T cell-based immunotherapy. It has become increasingly clear...

... of mRNA, microRNA (miRNA) and dozens of long non-coding RNA (LncRNA) were identified to be differentially regulated in PCSCs-like Panc-1 spheroid cells compared with their parental cells by HTS. Conclusions: Our results demonstrate an efficient enrichment and culture system for Panc-1 spheroid cells...

... positive and negative modulators. A better understanding of the regulatory mechanisms underlying Nrf2 activity could help to develop novel therapeutic interventions to prevent, slow down or possibly reverse various pathological states. To this end, microRNAs (miRs) are attractive candidates because...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Melatonin MicroRNAs Cardiac Progenitor Cells STAT3 H 2 O 2 MI MicroRNAs (miRNAs) are small RNAs containing about 22 nucleotides which do not encode proteins...

.... Subsequently, we analyzed these data using a combined bioinformatics approach and predicted the microRNAs (miRNAs) targeting the key gene using miRNA databases. Quantitative real-time PCR (qRT-PCR) was used to validate the expression of the top five DEGs. Results: In total, 1347 genes were identified as DEGs...

...Yuqiao Yang; Hongmei Chen; Nina Ding; Shuo Wang; Zhantao Duan; Yochai Birnbaum; Yumei Ye; Jinqiao Qian Background/Aims: Chronic heavy alcohol consumption may result in alcoholic cardiomyopathy. This study was designed to screen differentially expressed microRNAs and circular RNAs in heart tissue...

...Sungjin Park; SeongRyeol Moon; Kiyoung Lee; Ie Byung Park; Dae Ho Lee; Seungyoon Nam Background/Aims: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical...

...Lu Zhang; Hongli Yin; Lei Jiao; Tianyi Liu; Yuqiu Gao; Yingchun Shao; Yuanyuan Zhang; Hongli Shan; Ying Zhang; Baofeng Yang Background/Aims: Cardiac fibrosis is an important cardiac remodeling event that can ultimately lead to the development of severe arrhythmia and heart failure. MicroRNAs...

... of microRNAs after SCI has become a potential research focus. However, the underlying mechanisms are poorly understood. Methods: SCI models were established in rats using Allen’s method, and the BBB scoring method was employed to assess locomotor function. Lentivirus was used to infect rat astrocytes and SCI...

... by various cytokines and growth factors. However, the molecular basis of LR remains unclear. Emerging evidence indicates that microRNAs (miRNAs, miRs) are involved in controlling hepatocyte proliferation during LR. In this review, an overview is provided to cover recent achievements in studies on the roles...

...Jiandong Li; Liping Song; Ling Zhou; Jiaoxiang Wu; Chunjie Sheng; Huiming Chen; Yanjun Liu; Shijuan Gao; Wenlin Huang Background/Aims: MicroRNA (miRNA) is a small non-coding RNA molecule that functions in regulation of gene expression by targeting mRNA to affect its stability and/or translation...

...Yangang Wang; Donghua Xu; Bin Wang; Xu Hou MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals...

..., along with lots of cellular and molecular changes. Non-coding RNAs include small transcripts, such as microRNAs and a wide range of long non-coding RNAs (lncRNAs). Emerging evidence has revealed that non-coding RNAs acted as powerful and dynamic modifiers of cardiac aging. This review aims to provide...

...-CSCs. We also analyzed the microRNA (miR) targets of bufalin on the stemness of C1OS-CSCs. Moreover, we examined these findings in the OS specimen. Results: Bufalin inhibited the stemness of C1OS-CSCs. Moreover, we found that miR-148a appeared to be a target of bufalin, and miR-148a further regulated...

...Dong Ji; Bing Li; Qing Shao; Fan Li; Zhongbin Li; Guofeng Chen Background/Aims: New strategies for the prevention and treatment of cirrhosis are urgently needed for improving therapeutic outcome. A role of microRNAs (miRNAs) in the pathogenesis of cirrhosis has been recently acknowledged, whereas...

... 2+ signals were evaluated in isolated cardiomyocytes. Results: Systemic administration of ISO led to decreases in Rem protein and mRNA levels (down to 49%). Furthermore, levels of the microRNAs (miRs) miR-132 and miR-214 were upregulated 5- and 9-fold, respectively. Transfection of miR-132...

... and to elucidate the possible mechanism of their action. Methods: Cell proliferation was examined with a cell proliferation assay Cell Counting Kit-8 (CCK-8), propidium iodide (PI) staining was used to visualize cell cycle. The mRNA expression level of c-myc, c-fos, c-jun, GAPDH and microRNAs were measured...