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Cellular Physiology and Biochemistry (2019) 51 (6): 2829–2842.
Published Online: 18 December 2018
...-1283. 11 Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG: REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep 2009;10:866-872. 2840 Cellular Physiology Cell Physiol Biochem 2018;51:2829-2842 DOI...
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PIK3R3 enhanced the migration and invasion of PC cells. (A) PIK3R3 knockdow...
Published Online: 18 December 2018
Fig. 2. PIK3R3 enhanced the migration and invasion of PC cells. (A) PIK3R3 knockdown and overexpression respectively inhibited and promoted the migration and invasion of PC cells in vitro. (B) The effects of PIK3R3 on PC cell migration and invasion was investigated in vivo. (C) The expression ... More about this image found in PIK3R3 enhanced the migration and invasion of PC cells. (A) PIK3R3 knockdow...
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Verification of the DDP/gefitinib-resistant cell lines. MTT assays of A549,...
Published Online: 17 December 2018
Fig. 1. Verification of the DDP/gefitinib-resistant cell lines. MTT assays of A549, A549/DDP, HCC827, and HCC827/GR cells incubated with concentration gradients of DDP or gefitinib for 72 h. Results are presented as the mean ± SD (n = 3). *P< 0.05 and **P< 0.01. Fig. 1. Verification of ... More about this image found in Verification of the DDP/gefitinib-resistant cell lines. MTT assays of A549,...
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Differentially expressed miRNAs in A549, A549/DDP, HCC827, and HCC827/GR ce...
Published Online: 17 December 2018
Fig. 2. Differentially expressed miRNAs in A549, A549/DDP, HCC827, and HCC827/GR cells. (A) Venn diagram showing the numbers of expressed miRNAs in A549, A549/DDP, HCC827, and HCC827/GR cells. (B) Heat map displaying the differential expression and hierarchical clustering of miRNAs in A549, A54... More about this image found in Differentially expressed miRNAs in A549, A549/DDP, HCC827, and HCC827/GR ce...
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Expression of the same change trends of miRNAs in A549, A549/DDP, HCC827, a...
Published Online: 17 December 2018
Fig. 3. Expression of the same change trends of miRNAs in A549, A549/DDP, HCC827, and HCC827/GR cells. Venn diagram showing the numbers of upregulated miRNAs (A) and downregulated miRNAs (B) between Groups 1 and 2 with the criteria of fold change ≥ 2 and P< 0.05. Group 1 represents the diffe... More about this image found in Expression of the same change trends of miRNAs in A549, A549/DDP, HCC827, a...
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Validation of miRNA expression by qPCR. The results are expressed as the me...
Published Online: 17 December 2018
Fig. 4. Validation of miRNA expression by qPCR. The results are expressed as the mean ± SD deviation. The Student’s t-test was used to estimate significant differences among groups. P< 0.05 was considered statistically significant. Fig. 4. Validation of miRNA expression by qPCR. The result... More about this image found in Validation of miRNA expression by qPCR. The results are expressed as the me...
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GO enrichment analysis of the dysregulated miRNAs. GO enrichment analysis o...
Published Online: 17 December 2018
Fig. 5. GO enrichment analysis of the dysregulated miRNAs. GO enrichment analysis of the target genes corresponding to the upregulated miRNAs (A) and the downregulated miRNAs (B). Fig. 5. GO enrichment analysis of the dysregulated miRNAs. GO enrichment analysis of the target genes correspondi... More about this image found in GO enrichment analysis of the dysregulated miRNAs. GO enrichment analysis o...
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KEGG pathway analysis of the dysregulated miRNAs. KEGG pathway analysis of ...
Published Online: 17 December 2018
Fig. 6. KEGG pathway analysis of the dysregulated miRNAs. KEGG pathway analysis of the target genes corresponding to the upregulated miRNAs (A) and the downregulated miRNAs (B). Fig. 6. KEGG pathway analysis of the dysregulated miRNAs. KEGG pathway analysis of the target genes corresponding t... More about this image found in KEGG pathway analysis of the dysregulated miRNAs. KEGG pathway analysis of ...
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miRNA-mRNA co-expression network analysis involved in the Ras signaling pat...
Published Online: 17 December 2018
Fig. 7. miRNA-mRNA co-expression network analysis involved in the Ras signaling pathway. The miRNA-mRNA co-expression network analysis of the upregulated miRNAs (A) and downregulated miRNAs (B) was constructed by Cytoscape. Each yellow square represents representative miRNAs, each blue rhombus ... More about this image found in miRNA-mRNA co-expression network analysis involved in the Ras signaling pat...
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Expression levels of representative miRNAs in lung adenocarcinoma based on ...
Published Online: 17 December 2018
Fig. 8. Expression levels of representative miRNAs in lung adenocarcinoma based on the TCGA database. (A) hsa-mir-192; (B) hsa-mir-1293; (C) hsa-mir-194; (D) hsa-mir-561; (E) hsa-mir-205; (F) hsa-mir-30a; (G) hsa-mir-30c. The normal group and tumor group indicated adjacent non-tumor tissues and... More about this image found in Expression levels of representative miRNAs in lung adenocarcinoma based on ...
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Survival analysis of representative miRNAs in lung adenocarcinoma based on ...
Published Online: 17 December 2018
Fig. 9. Survival analysis of representative miRNAs in lung adenocarcinoma based on the TCGA database. (A) hsa-mir-192; (B) hsa-mir-1293; (C) hsa-mir-194; (D) hsa-mir-561; (E) hsa-mir-205; (F) hsa-mir-30a; (G) hsa-mir-30c. Statistics were calculated by the log-rank test. Fig. 9. Survival analy... More about this image found in Survival analysis of representative miRNAs in lung adenocarcinoma based on ...
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ROC analysis of representative miRNAs in lung adenocarcinoma based on TCGA ...
Published Online: 17 December 2018
Fig. 10. ROC analysis of representative miRNAs in lung adenocarcinoma based on TCGA database. (A) hsamir-192; (B) hsa-mir-1293; (C) hsa-mir-194; (D) hsa-mir-561; (E) hsa-mir-205; (F) hsa-mir-30a; (G) hsamir-30c. Fig. 10. ROC analysis of representative miRNAs in lung adenocarcinoma based on TC... More about this image found in ROC analysis of representative miRNAs in lung adenocarcinoma based on TCGA ...
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Cellular Physiology and Biochemistry (2019) 51 (6): 2872–2886.
Published Online: 14 December 2018
... pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling. Int J Oncol 2017;50:1821-1831. 23 Ou JM, Qui MK, Dai YX, Dong Q, Shen J, Dong P, Wang XF, Liu YB, Fei ZW: Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen. Int J...
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Cellular Physiology and Biochemistry (2019) 51 (6): 2900–2915.
Published Online: 14 December 2018
..., J.S. Chamberlain, P. Gregorevic: Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. J Cell Bio 2012; 197: 997-1008. 40. H. Gilson, O. Schakman, S. Kalista, P. Lause, K. Tsuchida, J.P. Thissen: Follistatin induces muscle hypertrophy through...
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