... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. K v 11.1 HERG Phosphorylation Protein kinase PKD Mass spectrometry Patch-clamp electrophysiology Primary antibodies: anti-K V 11.1, APC-062 (Alomone, Jerusalem, Israel, 1...

...Janire Urrutia; Aintzane Alday; Mónica Gallego; L. Layse Malagueta-Vieira; Ivan Arael Aréchiga-Figueroa; Oscar Casis; José Antonio Sánchez-Chapula Background: The rapid delayed rectifier K + current (I Kr ), carried by the hERG protein, is one of the main repolarising currents in the human heart...

...Yuan-Qi Shi; Meng Yan; Li-Rong Liu; Xiao Zhang; Xue Wang; Huai-Ze Geng; Xin Zhao; Bao-Xin Li Background/Aims: Abnormal QT prolongation is the most prominent cardiac electrical disturbance in patients with diabetes mellitus (DM). It is well known that the human ether-ago-go-related gene (hERG...

...Kaiping Zhang; Duo Zhi; Ting Huang; Yan Gong; Meng Yan; Chen Liu; Ting Wei; Zengxiang Dong; Baoxin Li; Baofeng Yang Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted...

...Liliang Shu; Wanzhe Zhang; Gang Su; Jingchao Zhang; Chao Liu; Jing Xu Background: Human ether-a-go-go-related gene (HERG) channel is the major molecular component of the native rapid delayed rectifier K + current (I Kr ) that is a crucial determinant of cardiac repolarization. Impairment of I Kr...

... membrane and proteins, as indicated by the overproduction of reactive oxygen species leading to severe lipid peroxidation and protein oxidation. Moreover, I Kr depression is most likely due to the dysfunction of HERG K + channel, the major subunit underlying native I Kr , in response to oxidative stress...

... of the CASQ2 mutations R33Q, F189L, and D307H, located in highly conserved regions, on the functions of cardiac potassium channels in Xenopus oocytes using two electrode voltage clamp. As a result, CASQ2 wild type and CASQ2-mutants modulated hERG functions differently. Free Ca 2+ measurements and molecular...

..., congestive heart failure and diabetic cardiomyopathy is associated with the abnormalities such as abnormal QT prolongation and increased risk of arrhythmias. To investigate how ceramide is involved in modulating cardiac repolarization, we performed whole-cell patch-clamp studies on HERG current (I HERG...

... KCNQ4 Kv7.1 Kv7.4 hERG Kv11.1 Kv1.5 Kv4.3 Cellular Physiology and Biochemistry Original Paper Cell Physiol Biochem 2008;21:47-54 Accepted: November 22, 2007 KCNE3 Mutation V17M Identified in a Patient with Lone Atrial Fibrillation Alicia Lundby1,2, Lasse Steen Ravn1,3, Jesper Hastrup...

... by methanesulfon-anilide antiarrhythmic drugs and several other common medications. I Ks activates very slowly, does not inactivate and is blocked by some benzodiazepines and a chromanol. HERG encodes subunits that form channels that mediate I Kr . KVLQT1 and minK encode subunits that coassemble to form channels...

..., and HERG, and the IsK subunit of the IKs-channel complex were expressed in Xenopus oocytes and two-electrode voltage-clamp experiments were performed. Verapamil induced a concentration-dependent block of Kv1.1-, Kv1.5-, IKs-, and HERG-induced currents with IC 50 values of 14.0 ± 2.7 μ M (n = 4), 5.1 ± 0.5...