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Keywords: bcl-2
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Cellular Physiology and Biochemistry (2018) 46 (1): 69–81.
Published Online: 20 March 2018
... of Mfn2 on cell apoptosis was investigated by flow cytometry. Flow cytometry was used to assess the change of the mitochondrial membrane potential of the cells treated with JC-1 assay. Mfn2, Bax, Bcl-2, cytochrome c, cleaved caspase-3, and cleaved caspase-9 protein levels were analysed by Western blot...
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Cellular Physiology and Biochemistry (2017) 42 (2): 660–672.
Published Online: 15 June 2017
... of miR-7 expression was an independent molecular biomarker for predicting the overall survival (OS) of LA patients. In addition, upregulation of miR-7 increases the sensitivity of LA cells to CDDP via induction of apoptosis by targeting Bcl-2. Conclusions: Our finding for the first time demonstrates...
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Cellular Physiology and Biochemistry (2017) 41 (6): 2211–2220.
Published Online: 25 April 2017
..., as well as main factors in NF-κB and JNK pathways were mainly determined by Western blotting. Besides, the relationship between Hsp27 and Bcl-2 was detected by co-immunoprecipitation. Results: LPS remarkably damaged HK-2 cells by reduction of cell viability, induction of apoptosis, and stimulation...
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Cellular Physiology and Biochemistry (2015) 37 (4): 1572–1580.
Published Online: 30 October 2015
... studied the levels of miR-429 and anti-apoptotic protein Bcl-2 in GC specimens. We performed bioinformatics analyses and used luciferase-reporter assay to analyze the relationship between miR-429 and Bcl-2 in GC cells. Cell survival upon Fluorouracil treatment was analyzed in a CCK assay. Cell apoptosis...
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Cellular Physiology and Biochemistry (2015) 37 (4): 1421–1430.
Published Online: 22 October 2015
... analyzed the levels of anti-apoptotic protein Bcl-2 and the levels of miR-429 in the purified CD31+ endothelial cells from mouse aorta. Prediction of the binding between miR-429 and 3'-UTR of Bcl-2 mRNA was performed by bioinformatics analyses and confirmed by a dual luciferase reporter assay. The effects...
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Cellular Physiology and Biochemistry (2015) 37 (2): 759–767.
Published Online: 11 September 2015
... are not completely understood. Methods: Here, we used a bleomycin-induced mouse model for ALI that has been published in our previous studies. We analyzed the mRNA and protein levels of an anti-apoptotic protein Bcl-2 in the ALI-mice that have been treated w/o ACE2. We analyzed miR-4262 levels in the mouse lung...
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Cellular Physiology and Biochemistry (2015) 37 (2): 641–650.
Published Online: 08 September 2015
... on the survival of mice in an acute leukemia model. We analyzed the effects of GRh2 on the cell viability of leukemia cell lines in vitro , using a CCK-8 assay and an MTT assay. We analyzed the effects of GRh2 on the apoptosis of leukemia cell lines in vitro , by flow cytometry. We analyzed the levels of Bcl-2...
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Cellular Physiology and Biochemistry (2015) 37 (1): 35–42.
Published Online: 12 August 2015
...-cycle suppressor p21 and p27, and increasing apoptosis-associated protein Bcl-2. MiR203 may also inhibit cell metastasis through suppressing matrix metalloproteinase 2 (MMP2), MMP7 and MMP9. Conclusion: Our data thus highlight miR203 as a novel therapeutic target for breast cancer. 17 03 2015...
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Cellular Physiology and Biochemistry (2015) 35 (5): 1958–1974.
Published Online: 27 March 2015
... inner membrane, decreased the level of cellular ATP, modulated the expression and phosphorylation of Bcl-2 leading to loss of its association with Bax and increased the release of cytochrome c to the cytosol of treated cells. The effects of 5‘-Cl on mitochondria and apoptosis were substantially blocked...
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Cellular Physiology and Biochemistry (2013) 32 (6): 1587–1599.
Published Online: 03 December 2013
... knockdown enhanced the inhibition of cell survival and increased the apoptosis induced by CDDP. Furthermore, the reduced survival rate correlated with reduced levels of phos-Akt Thr308 and phos-IκBa and reduced NF-κB p65 nuclear translocation. A decline in Bcl-2 and Bcl-xl expression and an increase in Bax...
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Cellular Physiology and Biochemistry (2012) 29 (3-4): 485–492.
Published Online: 03 April 2012
... apoptosis. Methods: Isolated and cultured rat coronary endothelial cells were used. Immunoblot techniques were used to study activation of mitogen-activated protein (MAP) kinases and to quantify PTHrP and PTHrP receptor expression. Real-time RT-PCR was used to quantify PTHrP, PTHrP-receptor, bcl-2, and bax...
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Cellular Physiology and Biochemistry (1996) 6 (6): 376–380.
Published Online: 04 September 2008
... of wild-type p53 activity was the first instance of a defect in the molecular machinery regulating susceptibility to apoptosis that was linked to the progression of gliomas and possibly their resistance to therapy. Further, expression of the antiapoptotic bcl-2 protein is likely to play a role...
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Cellular Physiology and Biochemistry (1996) 6 (6): 312–336.
Published Online: 04 September 2008
...Tarik Möröy; Martin Zörnig Bcl-2 had been discovered by analysing a chromosomal breakpoint characteristic for a specific human cancer. Its activity as an inhibitor of programmed cell death has considerably refined our concept how malignant neoplastic conditions develop. As Bcl-2 turns out...
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Cellular Physiology and Biochemistry (1999) 9 (6): 285–296.
Published Online: 23 December 1999
... was very low. In rat mesangial cells treatment with thapsigargin decreased the expression of BCL-2 protein and bcl-2 mRNA, whereas it did not alter the levels of BAX protein or bax mRNA. When mesangial cells were incubated with thapsigargin in the absence of FCS, we detected a significant increase...