..., IRF8 bound to the T-cell factor/lymphoid enhancer factor (TCF /LEF) promoter, thus repressing β-catenin nuclear translocation and its activation. IRF8 significantly disrupted the effects of Wnt agonist, bml284, further suggesting its involvement in the Wnt/β-catenin pathway. Conclusion: IRF8 acted...

... decreased SFRP2 reversed the epithelial-mesenchymal transition (EMT) process and stemness in JEG-3 and JAR cells both in vitro and vivo . Mechanistically, SFRP2 regulated the EMT and stemness of CC cell lines via canonical Wnt/β-catenin signaling, validated by the usage of a Wnt activator and inhibitor...

... cancer, miR-374a specifically targets WNT5, PTEN , and WIF1 genes, which are linked (by bioinformatic analysis) to negative regulation of the canonical Wnt/β-catenin signaling pathway [ 16 ]. This activates Wnt signaling, which induces the epithelial-mesenchymal transition and eventually increases...

... to in the content or advertisements. Wnt/β-catenin Radioresistance DNA repair ROS Apoptosis Radiotherapy is a powerful and common tool for the treatment of cancer. In fact, it is estimated that about one-half to two-thirds of cancer patients receive this type of therapy [ 1 ]. Although it has many...

... fibrosis and β-catenin levels. Moreover, the expression of S100A4 decreased after ICG-001 inhibited β-catenin signal pathway. Conclusion: Downregulation of S100A4 alleviates cardiac fibrosis via Wnt/β -catenin pathway in mice. S100A4 may be a therapeutic target of cardiac fibrosis. xudi@jsph.org.cn...

... of mineralization-related markers, increased alkaline phosphatase (ALP) activity, and enhanced ALP and Alizarin red staining. Panx3 was found to interact with the Wnt/β-catenin signaling pathway, forming a negative feedback loop. However, Wnt/β-catenin did not contribute to enhancement of osteogenic differentiation...

...Hualiang Xiao; Ying Zeng; Qiushi Wang; Shirong Wei; Xiangfeng Zhu Background/Aims: Neurotensin (NTS), an intestinal hormone, is profoundly implicated in cancer progression through binding its primary receptor NTSR1. The conserved Wnt/β-Catenin pathway regulates cell proliferation...

... -targeting small interfering RNA and a pcDNA3.1- Capn4 overexpression vector, respectively, to investigate its function in EOC in vitro . In addition, we investigated the potential mechanism underlying the function of Capn4 by examining the effect of modifying Capn4 expression on Wnt/β-catenin signaling...

...Can Wang; Yujuan Yue; Bianfei Shao; Zhu Qiu; Junhao Mu; Jun Tang; Xiaofan Han; Tingxiu Xiang; Guosheng Ren Background/Aims: Aberrant activation of the Wnt/β-catenin signaling pathway plays a key role in the pathogenesis of multiple tumors including digestive cancers. Recent studies have reported...

... in traditional Chinese medicine, but its mechanism remains unknown. The aim of this study was to probe the effect of icariin on the proliferation and differentiation of osteoblasts exposed to overload and to determine whether the Wnt/β-catenin signalling pathway is involved in the drug response in osteoblasts...

... by inhibiting the Wnt/β-catenin or Wnt5a/Ca 2+ pathways. 27 04 2015 17 7 2015 Psoriasis Keratinocyte Wnt5a/Ca 2+ pathway Wnt/β-catenin Psoriasis is characterized by abnormal growth, differentiation, and apoptosis of keratinocytes. Although the molecular basis...

... the levels of mRNAs encoding GSK-3β, AXIN2, β-catenin, TGF-β1, SMAD2, SMAD3, NOG (Noggin), and BMP4. Results: Cell density decreased dramatically as a function of the NaIO 3 dose. NaIO 3 increased apoptosis, inhibited mitosis, proliferation, and the Wnt/β-catenin pathway. CHIR99021 (Wnt agonist) treatment...