...-like receptors Gene expression Macrophages Adipocytes Adipose tissue Blood Innate immune system Obesity Inflammation Insulin resistance Type 2 diabetes Humans Toll-like receptors (TLR) are evolutionarily conserved receptors that play a key role in the innate immune response...

... of diabetic nephropathy (DN) during type 2 diabetes. In this pilot study we aim to assess whether miR-31 levels are modulated by the presence of DN and whether the expression of this miRNA is related to leukocyte-endothelial interactions and inflammation. Methods: Thirty-one T2D patients were enrolled...

...Pu Wang; Yu Cheng Lu; Jie Wang; Lan Wang; Hanry Yu; Yuan Fei Li; Alice Kong; Juliana Chan; Shaochin Lee Background/Aims: Type 2 diabetes is associated with oxidative stress and DNA damage which can cause centrosome amplification. Thus, the study investigated centrosome amplification in type 2...

... in a variety of biological functions and play key roles in many diseases, including type 2 diabetes (T2D). The aim of this study was to determine whether lncRNA-p3134 is associated with glucose metabolism and insulin signaling in pancreatic β cells. Methods: LncRNA microarray technology was used to identify...

... Type 2 Diabetes It is by now widely accepted, that the early life environment is not just an important factor affecting immediate birth outcomes, but is also associated with cardiovascular disease susceptibility in later life – for instance the likelihood of developing hypertension...

...Xiaoli Wang; Xiangyun Chang; Peipei Zhang; Ling Fan; Ting Zhou; Kan Sun Background/Aims: Long non-coding RNAs (lncRNAs) have emerged as key players in several biological processes and complex diseases. The risk of type 2 diabetes (T2D) is determined by a combination of environmental factors...

..., instructions or products referred to in the content or advertisements. Type 2 diabetes Adiponectin Antioxidation Insulin Diabetes mellitus (DM) was one of the first diseases to be documented, having been recorded in an Egyptian manuscript 3000 years ago. It is a chronic lifelong disease...

...Min Qi; Qiuhong Zhou; Weiqi Zeng; Minxue Shen; Xiaomin Liu; Chang Luo; Jing Long; Wangqing Chen; Jianglin Zhang; Siyu Yan Background: Recent evidence has indicated that long non-coding RNA (lncRNA) is involved in the pathogenesis of type 2 diabetes, but nothing is known about lncRNA expression...

... in type 2 diabetes has not been investigated extensively. The present study was designed to investigate the effects of Sal B on diabetes-related metabolic changes in a spontaneous model of type 2 diabetes, as well as its potential molecular mechanism. Methods: Male C57BL/KsJ- db/db mice were orally...

...Xiao Zhai; Guangfang Qian; Yiran Wang; Xiao Chen; Jiancan Lu; Yaping Zhang; Qin Huang; Qijin Wang Background/Aims: Despite strong association between obesity and the pathogenesis of type 2 diabetes (T2D), only a subset of obese individuals eventually develops T2D. We sought to determine...

... molecule 1 (STIM1) regulate platelet activity by modulating calcium influx. We hypothesized that enhanced SOCE in platelets is associated with diabetes with PAD. Methods: We studied the activity of platelets from healthy participants and from type 2 diabetic patients. Platelet calcium influx and protein...

... and eNOS dysfunction in endothelial cells from human umbilical vein [ 17 ]. Therefore, FGF21 has been proposed as a potential therapeutic target for the treatment of T2DM, obesity, and their associated complications, such as NAFLD. The prevalence of type 2 diabetes mellitus (T2DM) and obesity...

...Lei Wang; Ning Zhang; Hua-ping Pan; Zun Wang; Zhen-yu Cao Background: Type 2 diabetes afflicts 95% of diabetes patients. Recent data suggest that miRNAs play a key role in insulin production, secretion and function. This study aims to explore the specific role of miR-499-5p in hepatic insulin...

... of VSMCs. We tested the hypothesis that mesenteric VSMCs from type 2 diabetic Goto-Kakizaki (GK) rat undergo phenotypic modulation and it is linked to decreased caveolin-1 expression. Methods: VSMCs were isolated from mesenteric arteries from GK rats and age-matched control Wistar rats. Western blotting...

...-cells against oxidative stress, promote their survival, and increase insulin secretion in cell models of the glucotoxicity and glucolipotoxicity associated with Type 2 diabetes. * these authors contributed equally to this work 9 09 2011 15 12 2011 © 2011 S. Karger AG, Basel...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Farnesoid X receptor Glucose transporter 4 Type 2 diabetes Glucose metabolism Cellular Physiology and Biochemistry...

... in the treatment of type 2 diabetes, owing to its anti-hyperglycemic properties. However, the mechanism(s) underlying these metabolic effects remains unknown. Methods: The effects of silibinin on liver gluconeogenesis were studied by titrating hepatocytes from starved rats with sub-saturating concentrations...

... salt induced increase of blood pressure, glucocorticoid induced increase of electrogenic glucose transport, and glucocorticoid induced suppression of insulin release. The present study explored whether the I6CC/E8CC/CT haplotype impacts on the prevalence of type 2 diabetes. The prevalence of the I6CC...