... to chemotherapy [ 4, 5 ]. Therefore, it is important to identify prognostic and diagnostic molecular markers in HCC. microRNA-183 Tumor Suppressor Hepatocellular Carcinoma © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access License / Drug Dosage / Disclaimer This article...

... as a tumor suppressor gene through the transcriptional repression of β-catenin-TCF/LEF in NSCLC. IRF8 methylation may serve as a potential biomarker in NSCLC prognosis. [email protected] 29 06 2018 14 11 2018 22 11 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pcbp1 Tumor suppressor Prostate cancer Protein kinase 1 Prostate cancer (PCa) is one of the major causes...

...-330-3p suppressed osteosarcoma cell proliferation by directly targeting Bmi-1. Conclusion: Our results suggest that miR-330-3p acts as a tumor suppressor by regulating Bmi-1 expression in osteosarcoma. Thus, miR-330-3p may represent a novel therapeutic target for the treatment of osteosarcoma...

... (22.2%). Furthermore, patients with β2-microglobulin levels equal to or less than 3.5 mg/L had higher CEACAM1 expression than those with β2-microglobulin levels greater than 3.5 mg/L. Conclusion: Our findings suggest that CEACAM1 may act as a tumor suppressor in MM. Total RNA was extracted using...

... to the G0/G1 phase arrest. The expression of β-catenin, Cyclin D1, and c-Myc was suppressed by the overexpression of miR-214. Conclusion: These results suggested that miR-214 may serve as a tumor suppressor of ovarian cancer by targeting the β-catenin pathway. [email protected] 10 11 2017...

... promise for the innovation of early diagnostic approaches, and the development of more potential therapeutics for NPC. 23 08 2017 16 01 2018 9 2 2018 Nasopharyngeal carcinoma Long non-coding RNAs Oncogene Tumor suppressor Biomarkers Therapeutic targets...

... matrix assembly and degradation, connective tissue structuring, angiogenesis, and cell migration. Multiple studies suggest that ADAMTS proteins (e.g. ADAMTS9) can act as tumor suppressors. In gastric, esophageal, and nasopharyngeal carcinomas ADAMTS9 is frequently down-regulated by promoter methylation...

... function of osteosarcoma cells by inhibiting the expression of E2F2. Conclusion: Our results suggest that miR-125a acts as a tumor suppressor via regulation of E2F2 expression in osteosarcoma progression, and miR-125a may represent a novel therapeutic target for the treatment of osteosarcoma...

... in downregulation of active β-catenin and its downstream target genes. Conclusion: DKK2 appears to be a functional tumor suppressor regulating tumorigenesis of colorectal cancer by antagonizing Wnt/β-catenin signaling. [email protected] 2 11 2016 21 02 2017 30 3 2017 © 2017 The Author(s...

..., methods, instructions or products referred to in the content or advertisements. Osthole Osteosarcoma PTEN/Akt Tumor suppressor Cell cycle Migration and invasion Osteosarcoma is the most common form of primary malignant bone cancer which is most prevalent in children and adolescents...

... importantly, in vivo studies demonstrated that forced expression of miR-361-5p significantly inhibited tumor growth in the nude mice. Conclusion: Our results indicate that miR-361-5p acts as a tumor suppressor and might serve as a novel therapeutic target for the treatment of HCC patients. 4 01 2016...

... cancer which influenced the fate of tumor cells. On the one hand, oncogenic miR-100 increases cell proliferation through the pRb pathway by down-regulating SMARCA5, BAZ2A and THAP2; on the other hand, miR-100 could also act as a tumor suppressor, cooperating with other factors to down-regulate the mTOR...

... reversed the suppressive effects of miR-203. Furthermore, TBK1 was found up-regulated and inversely correlated with miR-203 in OS tissues. Conclusion: Taken together, these findings suggest that miR-203 acts as a tumor suppressor via regulation of TBK1 expression in OS progression, and miR-203 may...

.... Concolusion: In conclusion, RNF43 might act as a tumor suppressor in gastric carcinoma and might be a potential indicator for the clinical assessment of gastric cancer prognosis 11 05 2015 13 7 2015 For lentivirus construction, oligonucleotides with the following targeting sequences were used...

... were statistically analyzed. Next, we investigated whether miR-409-3p could function as a tumor suppressor in LAD cells via regulation of Akt signaling by targeting receptor tyrosine kinase (c-Met). Results: MiR-409-3p was significantly downregulated in LAD tissues compared with corresponding...

...Guoxing Xu; Jin Wang; Yixin Jia; Feng Shen; Wensheng Han; Yifan Kang Background/Aims: Mounting evidence has shown that aberrant expression of miRNAs correlates with human cancers, and that miRNAs can function as tumor suppressors or oncogenes. Here, we investigated the role and mechanism of miR-142...

... clock- controlled genes including tumor suppressor- and oncogenes. qRT-PCR of selected genes of interest, such as hPER2, hCRY1, hBMAL1, hCCRN4L and hSMAD5 revealed significant circadian regulations. Conclusion: Our study revealed a proper circadian regulation profile of several clock- and tumor...