... reported that the transient receptor potential channel vanilloid (TRPV5) is upregulated in monoiodoacetic acid (MIA)-induced OA articular cartilage. Methods: The protein levels of TRPV5, phosphorylated Ca 2+ /calmodulin-dependent kinase II (p-CaMKII), and total CaMKII were detected in vivo using western...

...Yingliang Wei; Dianbin Zheng; Xiaocheng Guo; Min Zhao; Linlin Gao; Lunhao Bai Background/Aims: Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca 2...

... transient receptor potential channel vanilloid 5 (TRPV5). Therefore, we investigated the potential role of TRPV5 in mediating Ca 2+ influx and in inhibiting chondrocyte autophagy in a rat OA model. Methods: The rat OA model was assessed by macroscopic and histological analyses. light chain 3B (LC3B...

... Sciences, University of Liverpool, UCD Building, Daulby St. Liverpool Key Words RVI RVD Cell Volume Regulation Membrane potential Ion channel Potassium ion channel TRPV4 TRPV5 TRPV6 Abstract Chondrocytes are the cells within cartilage which produce and maintain the extracellular matrix...