... that inhibition of the TGF-β pathway reduces epithelial-mesenchymal transformation. However, its potential role in EnMT remains poorly understood. As such, the effect of LY2109761, a novel TGF-β receptor type I and type II dual inhibitor, was investigated on EnMT. Methods: CECs cultured with various...

... cells, YXQ-EQ suppressed TGF-β/SMAD signaling and induced cell death in these cells in the presence of TGF-β1. Conclusion: Our findings suggest that YXQ-EQ could exert anti-lung cancer effects via inhibiting signaling pathways that are important for NSCLC cell survival and NSCLC metastasis. xwu1...

... to investigate the role of PAI-1 in the tumor microenvironment. Methods: The expression and distribution patterns of PAI-1 and transforming growth factor beta (TGF-β) were measured in 60 non-small cell lung cancer (NSCLC) tumors. A statistical correlation analysis was performed between PAI-1 and TGF-β expression...

...Go Sakai; Haruhiko Tokuda; Kazuhiko Fujita; Shingo Kainuma; Tetsu Kawabata; Rie Matsushima-Nishiwaki; Osamu Kozawa; Takanobu Otsuka Background/Aims: We previously demonstrated that transforming growth factor-β (TGF-β) stimulates the synthesis of vascular endothelial growth factor (VEGF) through...

... is unknown. Methods: In our study, we investigated the effects of Tisp40 on extracellular matrix (ECM) accumulation, epithelial-mesenchymal transition (EMT) and the underlying molecular mechanisms in transforming growth factor-β (TGF-β)-stimulated TCMK-1 cells by quantitative real-time polymerase chain...

...Rui Wang; Bin Xu; Hong-Gang Xu Background/Aims: This study aimed to explore the role of TGF-β in tendon-to-bone healing after anterior cruciate ligament (ACL) reconstruction using bone marrow-derived mesenchymal stem cells (BMSCs) through the TGF-β/MAPK signaling pathway in a New Zealand white...

...Kaizheng Gong; Mingxing Chen; Rujun Li; Yanghong He; Huajiang Zhu; Dan Yao; Suzanne Oparil; Zhengang Zhang Background: We have recently demonstrated that activated transforming growth factor-β (TGF-β) signaling suppresses myocardial peroxisome proliferator-activated receptor γ (PPARγ) expression...

..., instructions or products referred to in the content or advertisements. Muscle wasting TGF-β ng-(1-7) Mas receptor MHC MuRF-1 Skeletal muscle atrophy is a pathological condition that affects skeletal muscle, producing loss of strength and muscle mass and leading to weakness [ 1,2...

...Qi Zhou; Xiao Zheng; Lujun Chen; Bin Xu; Xin Yang; Jingting Jiang; Changping Wu Background/Aims: Transforming growth factor beta (TGF-β) plays a major role in tumorigenesis. MicroRNA-181b (miRNA-181b) is a multifaceted miRNA that has been implicated in many cellular processes such as cell fate...

...Min-Jin Kim; Sang-A Park; Chun Hwa Kim; So-Yeon Park; Jung-Shin Kim; Dae-Kee Kim; Jeong-Seok Nam; Yhun Yhong Sheen Background/Aims: Hypoxia is an environmental factor that aggravates liver fibrosis. HIF1α activates hepatic stellate cells (HSCs) and increases transforming growth factor-β (TGF-β...

... growth interacting factor 1 (TGIF1) gene. Tendon-to-bone insertion site is the special form of connective tissues derivatives of common connective progenitors, where TGF-β plays bidirectional effects (chondrogenic or fibrogenic) through different signaling pathways at different stages. A recent study...

...Omar García-Sánchez; Sandra M. Sancho-Martínez; José Miguel López-Novoa; Francisco J. López-Hernández Background/Aims: Defective tissue repair underlies renal tissue degeneration during chronic kidney disease (CKD) progression. Unbalanced presence of TGF-β opposes effective cell proliferation...

...Bo Hu; Changgui Shi; Ye Tian; Ying Zhang; Chen Xu; Huajiang Chen; Peng Cao; Wen Yuan Background/Aims: Chondroitin sulfate synthase 1 (CHSY1) is a glycosyltransferases involved in the biosynthesis of chondroitin and dermatan sulfate glycosaminoglycan (GAG). TGF-β can stimulate sulfated GAG...

...Qingfeng Hu; Shijun Tong; Xiaojun Zhao; Weihong Ding; Yuancheng Gou; Ke Xu; Chuanyu Sun; Guowei Xia Background: In our previous study, we found that periostin was upregulated in prostate cancer, and its expression could be modulated by TGF-β. TGF-β could upregulate periostin expression in some...

... factor β (TGF-β) called endothelial-to-mesenchymal transition (EndMT). We investigated whether the aldosterone receptor-blocker spironolactone could abrogate TGF-β-induced fibrosis in EndMT and the underlying mechanism. Methods : Human umbilical vein endothelial cells (HUVECs) were divided into 5 groups...

...Yinan Shen; Yongpeng Wei; Zhouchong Wang; Yingying Jing; Haiguan He; Jianyong Yuan; Rong Li; Qiudong Zhao; Lixin Wei; Tian Yang; Junhua Lu Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective of our study was to investigate whether TGF-β is able...

... nephropathy the activation of transforming growth factor-beta (TGF-β) has been demonstrated to promote podocyte death and the development of glomerulosclerosis. In this manuscript we analyzed the role of PKC-alpha (PKCα) on TGF-β1 induced apoptosis in podocytes. Methods: To accomplish this we generated stable...

...Hang Zhang; Ning Li; Yunan Tang; Weidong Wu; Qi Zhang; Zengli Yu We previously showed that atRA (all-trans Retinoic Acid, atRA) inhibites chondrogenesis by downregulation of TGF-β/Smad signaling. However, the molecular link between RA and TGF-β signaling is unknown. Using a mouse embryo palate...