...Qingqing Wang; Chengmei Lv; Yongxin Sun; Xu Han; Shan Wang; Zhengchun Mao; Yanming Xin; Bing Zhang Background/Aims: Ischemic stroke results in increased cerebral infarction, neurological deficits and neuroinflammation. The underlying mechanisms involving the anti-inflammatory and neuroprotective...

...) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular...

...Jiayan Wu; Junchao Xie; Yanxin Zhao; Li Gong; Xueyuan Liu; Wangmi Liu Background/Aims: Acute ischemic stroke is caused by stenosis of artery supplying to brain. We aimed to detect some metabolites in the serum that would be related to the degree of artery stenosis and to analyze potential...

... increased EPC function, promoted ischemic brain angiogenesis, protected against cerebral ischemic injury, and improved long-term stroke outcomes in young mice. In addition, transplanted EPCs from cold-exposed mice had a greater ability to reduce cerebral ischemic injury and promote local angiogenesis...

... functional recovery after ischemic stroke by attenuating oxidative damage, which is partially mediated by the Nrf2/HO-1 pathway. [email protected] 3 06 2017 18 07 2017 9 10 2017 © 2017 The Author(s). Published by S. Karger AG, Basel 2017 Open Access License / Drug Dosage...

...Wei He; Minzhi Lu; Guoqing Li; Zhigang Sun; Dinghua Liu; Lujun Gu Background/Aims: Genetic polymorphisms of methylene tetrahydrofolate reductase ( MTHFR ) were associated with ischemic stroke risk. This study analyzed MTHFR polymorphisms at the 3'-untranslated region for association with risk...

... MSCs to adopt a neural precursor fate and enhance the therapeutic effects of MSCs after experimental stroke. Methods: In vitro , MSCs were transfected with lenti-GFP or lenti-Ngn2. Following neuronal induction, cells were identified by immunocytochemistry, Western blot and electrophysiological analyses...

...XiaoPing Cui; HongJie Chen; Xuwei Hou; ShouSen Wang; Shoba Jayaram; ZhaoCong Zheng Background: Increasing evidence shows that inflammation plays an important role in the occurrence and progression of acute ischemic stroke. The receptor for advanced glycation end products (RAGE) has been documented...

...Fan Yang; Shuo Liu; Shur-Jen Wang; Chuanhui Yu; Annlia Paganini-Hill; Mark J. Fisher Background: Tissue plasminogen activator (tPA) regulates fibrinolysis and is routinely used as ischemic stroke pharmacotherapy. We hypothesized that brain microvascular tPA expression and barrier properties...