... resistance of CML cells to TKIs has limited their clinical application. Shikonin, a traditional Chinese herb, has long been used to treat leukemia in China, but the roles and related molecular mechanisms of shikonin treatment in CML remain unclear. Here, we aimed to evaluate the effects of shikonin...

...Yihui Bi; Yapeng Zhu; Mingkai Zhang; Keke Zhang; Xingyi Hua; Zheng Fang; Jian Zhou; Wenjie Dai; Yixing Cui; Jun Li; Tao You Background/Aims: Shikonin, a compound extracted from Zicao, has been demonstrated to hold anti-bacterial, anti-inflammatory, and anti-tumor activities in various diseases...

...Guangyao Zhou; Zuqin Yang; Xiaodong Wang; Ran Tao; Yuanping Zhou Background/Aims: Cholangiocarcinoma (CCA), arising from varying locations within the biliary tree, is the second most common primary liver malignancy worldwide. Shikonin, an active compound extracted from the Chinese herb Zicao, holds...

...Rachana Trivedi; Gerhard A. Müller; Manohar S. Rathore; Durga P. Mishra; Hassan Dihazi Background/Aims: ER-Stress and activation of unfolded protein response belong to the major factors involved in chemoresistance in cancer cells. In this study we investigated the effect of shikonin on the survival...

...Biyong Deng; Youwei Feng; Bixiang Deng Background/Aims: Osteosarcoma (OS) is a primary malignant bone tumor in humans, and is notorious mainly for its distal metastases. We have recently shown that Shikonin, an effective constituent extracted from Chinese medicinal herb, inhibits OS cell invasion...