...Hui Zhang; Cheng-Feng Xu; Chao Ren; Tian-Tian Wu; Ning Dong; Yong-Ming Yao Background/Aims: Immunosuppression frequently occurs during the development of sepsis and is closely associated with poor outcome. Characteristics of immunosuppressive CD4 + T lymphocytes in sepsis have been reported...

...Xi-Ling Wang; Li-Long Pan; Fen Long; Wei-Jun Wu; Di Yan; Peng Xu; Si-Yu Liu; Ming Qin; Wan-Wan Jia; Xin-Hua Liu; Yi Zhun Zu Background/Aims: Sepsis is a severe and complicated syndrome that is characterized by dysregulation of host inflammatory responses and organ failure. Cystathionine-γ-lyase...

...Ran Lv; Jinning Zhao; Min Lei; Dongju Xiao; Yijin Yu; Junran Xie Background/Aims: Sepsis is a systemic inflammatory response during infection. There are limited therapeutic options for sepsis patients. Interleukin (IL)-33 has been reported recently with a beneficial effect in mouse sepsis. Methods...

...Yi Chen; Lei Wang; Qiuxiang Kang; Xu Zhang; Guifang Yu; Xiaojian Wan; Jiafeng Wang; Keming Zhu Background: Pulmonary endothelial injury is a critical process in the pathogenesis of acute lung injury (ALI) during sepsis. Heat shock protein A12B (HSPA12B) is mainly expressed in endothelial cells...

...Yiming Shao; Junbing He; Feng Chen; Yujie Cai; Jianghao Zhao; Yao Lin; Zihan Yin; Hua Tao; Xin Shao; Pengru Huang; Mingkang Yin; Wenying Zhang; Zhou Liu; Lili Cui Background: A disintegrin and metalloproteinase 17 (ADAM17) has been confirmed to play a significant role in the pathogenesis of sepsis...

... plus surfactant yielded all of the aforementioned beneficial effects, as well as increased BALF lipid content and reduced surface tension. Conclusion: LASSBio596 exhibited major anti-inflammatory and anti-fibrogenic effects in experimental sepsis-induced ARDS. Its association with surfactant may...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Escin High motility group box 1(HMGB1) Sepsis NF-κB Despite extensive research...

... count in the peripheral blood was determined. Data are presented as means ± SEM for 3-5 animals per group. *P < 0.05 sham versus other groups. 12 05 2015 6 7 2015 Table 2 Effect of CLP-induced sepsis on blood glucose levels (mg/dL) in diabetic and non-diabetic rats. Rats...

...Jiang Zhu; Guangjie Duan; Lang Lang; Yao Liu; Junmin Zhu; Hu Wang; Yousheng Liu Background: The present study was designed to observe the effects of the bacterial component flagellin on anti-sepsis protection through TLR-5, VCAN and IL-1RN. Methods: A clinically relevant model of sepsis was induced...

... inflammation, similar to those observed during sepsis, can develop in the absence of an invasive infection e.g. in pancreatitis or severe trauma. This finding led to the concept of a systemic inflammatory response syndrome (SIRS) [ 3,4 ]. Likewise the toxic effect of Lipopolysaccharide (LPS) is due...

... Sepsis Phagocytosis Cytokines NF-ĸB MAPK Akt PKC Insulin Diabetes Mellitus Alveolar macrophages Cellular Physiology and Biochemistry Review Cell Physiol Biochem 2012;29:01-08 Accepted: November 21, 2011 Briefs on Insulin and Innate Immune Response Karen K. S. Sunahara1, Paulina Sannomiya2...

... is stimulated in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle-cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase (G6PD)-deficiency, phosphate depletion, iron deficiency and Wilson’s disease. Moreover, eryptosis is elicited by osmotic shock, oxidative...

... that analysis of enhanced eryptosis may direct to the pathophysiology of systemic disease. Examples presented include drug side effects, sepsis, haemolytic uremic syndrome, Wilson´s disease, phosphate depletion and a rare condition caused by a mutation in GLUT1 turning the carrier into a cation channel. ©...