...Guo Zu; Tingting Zhou; Ningwei Che; Xiangwen Zhang Background/Aims: Ischemia-reperfusion (I/R) adversely affects the intestinal mucosa. The major mechanisms of I/R are the generation of reactive oxygen species (ROS) and apoptosis. Salvianolic acid A (SalA) is suggested to be an effective...

... glycation end products (AGEs) and receptor for AGEs (RAGE) are proved to play important roles in diabetic nephropathy. This study investigated the role of Salvianolic acid A (SalA) on early-stage DN and its possible underlying mechanism. Methods: In vitro AGEs formation and breaking rate were measured...

...Jing-yi Zhang; Gui-bo Sun; Yun Luo; Min Wang; Wei Wang; Yu-yang Du; Ying-li Yu; Xiao-bo Sun Background/Aims: This study aimed to investigate whether Salvianolic acid A (Sal A) conferred cardiac protection against Arsenic trioxide (ATO)-induced cardiotoxicity in H9c2 cells by inhibiting MAPK...

...Guifen Qiang; Xiuying Yang; Lili Shi; Hengai Zhang; Bainian Chen; Yan Zhao; Mian Zu; Dan Zhou; Jing Guo; Haiguang Yang; Li Zhang; Guanhua Du Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA...

...Ping Xie; Yingchun Duan; Xianzhi Guo; Lina Hu; Minghua Yu Background: Salvianolic acid A (SalA) has been shown to display robust protection against endothelial injury. VLDL receptor (VLDLr) is expressed at high levels in the endothelial cells. However its endothelial biological function has...

...Dan Yang; Peng Zhang; Tingfeng Wang; Lili Gao; Zhengdong Qiao; Yongjun Liang; Bo Yu Background: Salvianolic acid A (SalA) has been shown to confer robust protection against endothelial injury. VLDL receptor is expressed at high levels on the endothelial surface, however its biological effect...