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Keywords: SIRT1
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Cellular Physiology and Biochemistry (2018) 51 (5): 2397–2420.
Published Online: 11 December 2018
... of SIRT1 and ATF6 with small interfering RNAs or overexpressed plasmids, respectively. The dual luciferase reporter assay, chromatin immunoprecipitation assay, coimmunoprecipitation, and proximity ligation assay were utilized to clarify the mechanism of transcriptional regulation and possible interaction...
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Cellular Physiology and Biochemistry (2018) 49 (6): 2151–2162.
Published Online: 26 September 2018
... . The enforced expression of miR-128 sensitized CRC cells to TRAIL-induced cytotoxicity by inducing apoptosis. Mechanistically, bioinformatics, western blot analysis, and luciferase reporter assays showed that miR-128 directly targeted sirtuin 1 (SIRT1) in CRC cells. miR-128 overexpression suppressed SIRT1...
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Cellular Physiology and Biochemistry (2018) 49 (3): 1037–1047.
Published Online: 07 September 2018
...: Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. The direct binding of HIF1α on Sirt1 promoter was validated by ChIP assay. The inhibitory regulation of Sirt1 by HIF1α was analyzed using luciferase reporter assay. The endogenous protein of HIF1α and Sirt1...
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Cellular Physiology and Biochemistry (2018) 48 (1): 304–316.
Published Online: 17 July 2018
...Kaihua Ji; Xiaohui Sun; Yang Liu; Liqing Du; Yan Wang; Ningning He; Jinhan Wang; Chang Xu; Qiang Liu Background/Aims: SirT1, a conserved NAD + -dependent deacetylase, has been implicated in modulating cell survival and stress responses, and it appears to play an important role in tumorigenesis...
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Cellular Physiology and Biochemistry (2018) 47 (3): 1193–1206.
Published Online: 15 June 2018
...), and attenuate mitochondrial oxidative damage by elevating superoxide dismutase (SOD) activity and reducing production of hydrogen peroxide (H 2 O 2 ) and malonaldehyde (MDA). Moreover, the cardioprotective effect of TQ was accompanied by up-regulated expression of SIRT1 and inhibition of p53 acetylation...
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Cellular Physiology and Biochemistry (2017) 43 (2): 852–869.
Published Online: 28 September 2017
... to examine the expression of Sirt1 and Shh signaling proteins. Results: Resveratrol and the Smoothened (Smo) agonist purmophamine, which activates Shh signaling, increased viability, reduced apoptosis, and stimulated neurite outgrowth after OGD/R injury. Moreover, the expression of growth-associated protein...
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Cellular Physiology and Biochemistry (2017) 43 (2): 644–659.
Published Online: 22 September 2017
...) were assessed colorimetrically, while fibroblast growth factor (FGF)-21, adiponectin & interleukin (IL)-6 via ELISA. The same technique was used for the assays of the hepatic levels of FGF-21, silent information regulator (SIRT1), malondialdehyde (MDA),IL-10, tumor necrosis factor-α (TNF-α) as well...
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Cellular Physiology and Biochemistry (2017) 42 (1): 34–43.
Published Online: 10 May 2017
... tissue. SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase-1 cleavage as well as interleukin (IL)-1β secretion both in vivo and in vitro . Moreover, SDS administration up-regulated SIRT1 expression. Importantly, knockdown of SIRT1 reversed the inhibitory effect of SDS...
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Cellular Physiology and Biochemistry (2017) 41 (2): 795–805.
Published Online: 14 February 2017
...-III deacetylase SIRT1 regulates EMT in ovarian cancer (OC) cells. Methods: Expression analysis was performed using Q-PCR, western blot, immunofluorescence and fluorescence-IHC study. Matrigel invasion assay was used for the invasion study. Morphological alterations were observed by phalloidin-staining...
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Cellular Physiology and Biochemistry (2017) 41 (1): 310–322.
Published Online: 24 January 2017
.... Recent studies have demonstrated an interaction between hepatitis B virus replication and autophagy activity of hepatocytes. In the present study, we aimed to investigate the role of miR-141 in regulating autophagy and hepatitis B virus replication. Methods : The expression of HBV-DNA, miR-141 and Sirt1...
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