... tumor types. The present study explored whether SGK1 is expressed in rhabdomyosarcoma and, if so, whether this kinase impacts on tumor cell survival, proliferation and migration. Multiple in vitro techniques were used to study the role of SGK1 in rhabdomyosarcoma. Methods: The Gene Chip® Human Genome...

... therapy. Glioblastoma multiforme (GBM) is the CNS tumor with the worse prognosis, characterized by high number of recurrences and strong resistance to chemo-radio therapy, strongly affecting patients survival. We have recently discovered and studied the small molecule SI113, as inhibitor of SGK1, a serine...

... is dependent on a signaling cascade including p38 kinase, serum & glucocorticoid inducible kinase SGK1, and nuclear factor NFκB. The specific Na + /Ca 2+ exchanger isoforms involved and the signalling regulating the Na + /Ca 2+ exchangers remained, however elusive. The present study explored, whether TGFβ1...

.... Chorein is effective in part by interacting with and fostering stimulation of phosphoinositide-3-kinase (PI3K)-p85-subunit. PI3K dependent signaling includes the serum and glucocorticoid inducible kinase SGK1. The kinase activates NFκB with subsequent up-regulation of the Ca 2+ channel subunit Orai1...

...Cristina Talarico; Vincenzo Dattilo; Lucia D'Antona; Miranda Menniti; Cataldo Bianco; Francesco Ortuso; Stefano Alcaro; Silvia Schenone; Nicola Perrotti; Rosario Amato The serum- and glucocorticoid-regulated kinase (SGK) family consists of three members, SGK1, SGK2 and SGK3, all displaying serine...

...Madhuri S. Salker; Zohreh Hosseinzadeh; Nour Alowayed; Ni Zeng; Anja T. Umbach; Zoe Webster; Yogesh Singh; Jan J. Brosens; Florian Lang Background: Serum & glucocorticoid inducible kinase (SGK1) regulates several ion channels, including amiloride sensitive epithelial Na + channel (ENaC). SGK1...

...Jakob Voelkl; Tatsiana Castor; Katharina Musculus; Robert Viereck; Sobuj Mia; Martina Feger; Ioana Alesutan; Florian Lang Background/Aims: The serum- and glucocorticoid-inducible kinase SGK1 participates in the orchestration of cardiac hypertrophy and remodeling. Signaling linking SGK1 activity...

... Perrotti Background/Aims: Published observations on serum and glucocorticoid regulated kinase 1 (Sgk1) knockout murine models and Sgk1-specific RNA silencing in the RKO human colon carcinoma cell line point to this kinase as a central player in colon carcinogenesis and in resistance to taxanes. Methods...

...Wei Zhang; Chuan yun Qian; Shu qing Li Background/Aims : To investigate the protective effect of SGK1 (serum- and glucocorticoid-inducible protein kinase 1) in rat hippocampal neurons in vitro and in vivo following ischemia reperfusion (I/R). Methods: Isolated rat hippocampal neurons were subjected...

... in culture medium and was mediated by SGK1/Nedd4-2 pathway stimulation. In these conditions, rosiglitazone induced SGK1 expression, Nedd4-2 phosphorylation and thus abolished ubiquitylation and internalization of ENaC channels. This mechanism explains most of the side effects of thiazolidinediones previously...

...Jakob Voelkl; Venkanna Pasham; Mohamed Siyabeldin E. Ahmed; Britta Walker; Kalina Szteyn; Dietmar Kuhl; Bernhard Metzler; Ioana Alesutan; Florian Lang Background/Aims: The serum- and glucocorticoid-inducible kinase Sgk1 contributes to cardiac remodeling and development of heart failure, which...

... is inhibited by vinculin, which is similarly regulated by phosphorylation. PI3K-sensitive kinases include the serum- and glucocorticoid-inducible kinase 1 (SGK1). The present study explored whether SGK1 modifies WASP and vinculin phosphorylation in murine platelets and participates in the regulation...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Dehydration Cell volume SGK1 Forkhead box P1 Serpinh1 Gap junction protein beta 1 * contributed equally...

...Miranda Menniti; Rodolfo Iuliano; Michael Föller; Mentor Sopjani; Ioana Alesutan; Stefania Mariggiò; Charity Nofziger; Angela M. Perri; Rosario Amato; Bonnie Blazer-Yost; Daniela Corda; Florian Lang; Nicola Perrotti The serum- and glucocorticoid-regulated kinase (Sgk1) is essential for hormonal...

...Krisztina Rusai; Bettina Wagner; Marcel Roos; Christoph Schmaderer; Matthias Strobl; Krishna M. Boini; Almut Grenz; Dietmar Kuhl; Uwe Heemann; Florian Lang; Jens Lutz The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine threonine protein kinase activated through...

... of the serum and glucocorticoid inducible kinase SGK1, which could in turn enhance gastric acid secretion by stimulating KCNQ1 K + channels. The present study explored whether pioglitazone upregulates SGK1 protein expression in gastric glands and thus modifies gastric acid secretion. Food containing the PPARγ...

.... NHERF2 elevates Kv1.5 abundance at the plasma membrane by decreasing channel internalization as proven by Brefeldin A experiments. Kv1.5 is stimulated by the serum and glucocorticoid inducible kinase SGK1, a kinase known to interact with the second PDZ domain of NHERF2. This study aims to identify...

...Matthias Schwab; Adrian Lupescu; Maria Mota; Eugen Mota; Andreas Frey; Perikles Simon; Peter R. Mertens; Jürgen Floege; Friedrich Luft; Steven Asante-Poku; Elke Schaeffeler; Florian Lang The serum and glucocorticoid inducible kinase SGK1 is genomically upregulated by glucocorticoids and in turn...

...Perikles Simon; Michaela Schneck; Tabea Hochstetter; Evgenia Koutsouki; Michel Mittelbronn; Axel Merseburger; Cora Weigert; Andreas Niess; Florian Lang The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a key-regulator of transport, cell volume and cell survival. SGK1 transcription is under...