...Liping Wang; Chunyan Wang; Xuqiang Jia; Jing Yu Background/Aims: A reduced prevalence of circulating regulatory T cells (Tregs)is a hallmark of inflammatory rheumatoid arthritis (RA). However, the underlying mechanisms of alterations of Tregs are unclear. Methods: The ratio of Tregs in peripheral...

...Ting Guo; Hao Ding; Hui Jiang; Nirong Bao; Liwu Zhou; Jianning Zhao Background/Aims: MicroRNAs (miRNAs) have been reported to be involved in Rheumatoid arthritis (RA) pathogenesis and prognosis. However, little is known about the disease mechanism in RA. Here, we aim to investigate the potential...

..., including blood and synovial fluids. Increasing knowledge is emerging about exosomes in joint diseases, including osteoarthritis, rheumatoid arthritis, osteonecrosis of the femoral head, and others. Exosomes in synovial fluid can lead to inflammation, degeneration of cartilage, and destruction of joints...

...Olfat Gamil Shaker; Noha Ahmed EL Boghdady; Abeer El-Dessouki El Sayed Background/Aims: Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting up to 1% of the population worldwide. The aim of the present study was to investigate whether miRNA-146a rs2910164, miRNA-499 rs3746444, IRAK1...

...Nadine Beckmann; Katrin Anne Becker; Silke Walter; Jan U. Becker; Melanie Kramer; Gabriele Hessler; Stefanie Weber; Joachim R. Göthert; Klaus Fassbender; Erich Gulbins; Alexander Carpinteiro Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial...

... in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients to identify novel biomarkers for RA screening. Methods: We started with a microarray screening of circRNA changes in PBMCs from 5 RA patients and 5 healthy controls. We then confirmed the selected circRNA changes in PBMCs from...

...) and expressions of pro-inflammatory cytokines in rheumatoid arthritis (RA) rats via microRNA-22 (miR-22). Methods: A rat model of RA was established with a subcutaneous injection of type II collagen. After treated with different concentrations of 1,25-(OH) 2 D 3 the proliferation of FLS was estimated by the MTT...

... in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-35 is an anti-inflammatory cytokine that attenuates collagen-induced arthritis, however, the mechanisms involved are not fully understood. Methods: The effects of IL-35 on endothelial cell migration, adhesion, and tube formation were examined using...

...Xiao-Jie He; Yan Ding; Wei Xiang; Xi-Qiang Dang Background/Aims: The study aims to elucidate the roles of 1,25(OH) 2 D 3 and vitamin D receptor (VDR) in the pathogenesis of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) by regulating the activation of CD4 + T cells and the PKCδ...

...Chuqi Yan; Dechao Kong; Dong Ge; Yanming Zhang; Xishan Zhang; Changhui Su; Xiaojian Cao Background/Aims: Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterised by prominent synoviocyte hyperplasia and a potential imbalance between the growth and death of fibroblast-like...