.... Our previous studies suggested that resveratrol (RSV) supplement could improve hepatic steatosis, but the underlying mechanism, particularly which related to LD accumulation, has not yet been elucidated. Methods: A high-fat diet (HFD) and palmitic acid were used to induce hepatic steatosis in mouse...

... was much more important for hindering regeneration after brain or spinal cord injury than the astrocytic scar. However, it has been given much less attention for effects and mechanism of fibroblasts during formation of the fibrotic scar. Resveratrol may be a potential anti-scarring agent in burn-related...

...Kui Xu; Xiu-fen Liu; Zhi-qiang Ke; Qing Yao; Shuang Guo; Chao Liu Background/Aims: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects in various cardiovascular diseases. This study...

... inflammatory responses, oxidative stress, and metabolic disorders. Resveratrol (RSV) plays an important role in protecting various organs in IRI because it reduces oxidative stress, lessens the inflammatory response, and exerts anti-apoptotic effects. The aim of this study was to demonstrate the renoprotective...

...Tetsu Kawabata; Haruhiko Tokuda; Kazuhiko Fujita; Shingo Kainuma; Go Sakai; Rie Matsushima-Nishiwaki; Osamu Kozawa; Takanobu Otsuka Background/Aims: Resveratrol is a polyphenol enriched in the skins of grapes and berries, that shows various beneficial effects for human health. In the present study...

...Fanren Tang; Shuang Guo; Hongyan Liao; Pingping Yu; Li Wang; Xiaosong Song; Jixiang Chen; Qin Yang Background/Aims: Neurite outgrowth and synaptogenesis are critical steps for functional recovery after stroke. Resveratrol promotes neurite outgrowth and synaptogenesis, but the underlying mechanism...

...Zhiyan Tian; Jinhua Wang; Ming Xu; Yan Wang; Miao Zhang; Yuying Zhou Aims: To investigate the effects of resveratrol on cognitive impairment in streptozotocin (STZ)-induced diabetic rats and to explore the mechanisms of that phenomenon. Methods: Sixty healthy male Sprague Dawley rats were randomly...

...Yan Lin; Jingbin Zhu; Xiaojie Zhang; Jun Wang; Wei Xiao; Bo Li; Li Jin; Jie Lian; Li Zhou; Jicheng Liu Background/Aims: Resveratrol (Res), a polyphenol antioxidant found in red wine, has been shown to play a cardioprotective role. This study was undertaken to investigate whether Res can protect...

... the formation of intra-abdominal adhesions. Resveratrol is a natural extract with a broad range of anti-inflammatory effects. Therefore, we propose that resveratrol can reduce the formation of intra-abdominal adhesions after surgery. The aim of this study was to investigate the effect of resveratrol on intra...

... male and female rats. Moreover, we tested whether resveratrol has a gender-specific effectiveness on the alterations. Methods: Male and female rats were divided into four groups as control; resveratrol; fructose and resveratrol plus fructose. Fructose was given to the rats as 10% solution in drinking...

...Peng Wang; Dunlin Ren; Ying Chen; Meiju Jiang; Robin Wang; Yan-Gang Wang Objective: Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties. We performed an animal study...

...Peipei Nie; Weicheng Hu; Tao Zhang; Yiju Yang; Benxin Hou; Zhengzhi Zou Background/Aim: Treatment of human non-small-cell lung cancer (NSCLC) often involves uses of multiple therapeutic strategies with different mechanisms of action. Here we found that resveratrol (RV) enhanced the anti-tumor...

... of the glycolytic enzyme pyruvate dehydrogenase (PDH). In contrast, how aging would regulate acetylation/deacetylation machineries and glucose utilization in skeletal muscle through the Foxo1/PDH axis remains largely undetermined. Accumulating body of evidence have shown that resveratrol, a natural polyphenol...

...Ran Wang; Yan-yan Liu; Xiao-yu Liu; Shu-wei Jia; Jian Zhao; Dan Cui; Ling Wang Background: Resveratrol has shown potent antioxidant activity in ischemia models. The present study was performed to determine whether resveratrol protects against cerebral ischemia-induced neuronal and myocardial injury...

...Rong Guo; Yang Su; Baoxin Liu; Shuang Li; Shunping Zhou; Yawei Xu Background/Aim: Resveratrol (RSV) may have therapeutic potential for various diseases. Here we investigated the effect of RSV on oxidised low-density lipoprotein- (ox-LDL) induced apoptosis in RAW264.7 macrophages. Methods: Apoptosis...

...Ying Yang; Shuping Li; Qiao Yang; Yu Shi; Min Zheng; Yanning Liu; Feng Chen; Guangzhong Song; Hangdi Xu; Tianhong Wan; Jiliang He; Zhi Chen Background: Resveratrol (Res) is a polyphenol anti-inflammatory agent. We have studied the link between the anti-inflammatory effects of Res and the high...

...Jing Zhang; Jing Chen; Jian Yang; Chang-Wu Xu; Peng Pu; Jia-Wang Ding; Hong Jiang Background/Aim: Oxidative stress plays a critical role in pathogenesis of the neointimal arterial hyperplasia. The aim of the study was to evaluate effects of resveratrol (RSV) on the vascular hyperplasia stimulated...

...-fluorouracil (5-FU) with resveratrol ( trans -3, 4′, 5-trihydroxystilbene) for treating HT-29 and SW-620 colorectal carcinoma cell lines. Since combined treatment using 5-FU with resveratrol resulted in a significant decrease in long-term cell survival, we investigated the possible basis of this synergistic...

...Cornelia Bortolotti; Thomas Kunit; Angelika Moder; Clemens Hufnagl; Sabine Schmidt; Arnulf Hartl; Christian Langelueddecke; Johannes Fürst; John Geibel; Markus Ritter; Martin Jakab We investigated the effect of resveratrol on proliferation and induction of apoptosis of INS-1E rat insulinoma cells...

...Martin Jakab; Sibylle Lach; Zuzana Bacová; Christian Langelüddecke; Vladimir Strbák; Sabine Schmidt; Eva Iglseder; Markus Paulmichl; John Geibel; Markus Ritter The phytostilbene resveratrol (RV) improves the metabolic state in animal models by increasing the insulin responsiveness of tissues...