... of isoflavonoid, could be used as an inducer of hepatic Ltf expression through cooperation with the GH signaling pathway both in vitro and in vivo . Conclusions : Hepatic Ltf prevents hepatic steatosis through inhibition of dietary lipid uptake in radiation-induced NAFLD mouse model. We also suggest coumestrol...

...Jicong Du; Ying Cheng; Suhe Dong; Pei Zhang; Jiaming Guo; Jiaqi Han; Fu Gao; Hainan Zhao; Ding Sun; Jianguo Cui; Jianming Cai; Cong Liu Background/Aims: The hematopoietic system is vulnerable to ionizing radiation and is often severely damaged by radiation. Molecules affecting radioresistance...

... the effects of endotoxin contamination, both in vitro and in vivo . Lipopolysaccharide (LPS) is an endotoxin that acts as a radiation protection factor. In this study, we focus on the role of PMB in LPS-induced and radiation-induced mortality in mice. Methods: Mice received total-body radiation or were...

... is also over-expressed in human solid tumors, although its effect on responsiveness to radiation is largely unexplored. Methods: Real-time PCR was used to detect ATF4 mRNA levels in cells treated with different doses of 60 Coγ radiation. Cell viability was assayed using a cell counting kit. The cell cycle...

...Bao-Feng Wang; Xi-jing Wang; Hua-Feng Kang; Ming-Hua Bai; Hai-Tao Guan; Zhong-Wei Wang; Ying Zan; Ling-Qin Song; Wei-Li Min; Shuai Lin; Yan-An Cheng Background: Our previous study revealed that the combination of Saikosaponin-d ( SSd) and radiation is more effective in the treatment of liver cancer...

...Bailong Li; Chaoxiong Zhang; Feng He; Wen Liu; Yanyong Yang; Hu Liu; Xin Liu; Jie Wang; Lin Zhang; Bo Deng; Fu Gao; Jianguo Cui; Cong Liu; Jianming Cai Background: Exposure of high dose ionizing radiation is lethal. Signal pathways involved in radiation biology reaction still remain illdefined...

... affects survival of colon carcinoma cells in vitro and impacts on development of colonic tumors in vivo . Methods: Colon carcinoma (Caco-2) cells were exposed to EMD638683 with or without exposure to radiation (3 Gray) and cell volume was estimated from forward scatter, phosphatidylserine exposure from...

... cells/supernatants were investigated at days 2 and 4 after irradiation/start of treatment with sunitinib. Control cells were investigated at the same time points. Thyroid cancer Sunitinib Cytokines Radiation VEGF Gene expression For irradiation, X-rays generated at a dose rate of 3 Gy...