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1-20 of 27
Keywords: Protein kinase C
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Journal Articles
Subject Area:
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2018) 47 (3): 994–1006.
Published Online: 24 May 2018
... the effects of inhalation of H 2 S on CA and resuscitation in a rat model of CA. We used Evans blue to detect the integrity of BBB and Western blot to assess the activation of protein kinase c (PKC) isozymes and the expression of Claudin-5, Occludin, and ZO-1. Neurological deficit scales and the 14-days...
Journal Articles
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Mengwen Qi, Chunfeng Wu, Zhouqing Wang, Li Zhou, Chen Men, Yimei Du, Songming Huang, Lei Chen, Ling Chen
Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2018) 45 (3): 1084–1096.
Published Online: 07 February 2018
... was significantly attenuated by protein kinase C (PKC) (BIM II or D-sphingosine) or calcium/calmodulin-dependent protein kinase II (CaMKII) (KN-62 or KN-93) antagonists but was unaffected by protein kinase A or protein tyrosine kinase antagonists. Finally, hippocampal protein levels of GlyR α1 α2, α3 and β subunits...
Journal Articles
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 42 (4): 1493–1513.
Published Online: 18 July 2017
... to VEGF-A 165 , e.g. inhibiting protein kinase C only prevented the early response. High concentrations of some inhibitors even resulted in VEGF-independent barrier destabilization. Conclusions: Specific kinase inhibitors differently affect VEGF-A 165 -triggered processes in distinct phases of its action...
Journal Articles
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Krishna P. Subedi, Min-Jeong Son, Bojjibabu Chidipi, Seong-Woo Kim, Jun Wang, Kyeong-Hee Kim, Sun-Hee Woo, Joon-Chul Kim
Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 41 (1): 399–412.
Published Online: 26 January 2017
... ventricular myocytes. Results: ET-1 and PE increased CREB phosphorylation, which was inhibited by blockade of phospholipase C, the extracellular-signal-regulated kinase 1/2 (ERK1/2) pathway, protein kinase C (PKC) or Ca 2+ -calmodulin-dependent protein kinase II (CaMKII). Intracellular Ca 2+ buffering...
Journal Articles
Novel Insights in the Regulation of Phosphatidylserine Exposure in Human Red Blood Cells
Open AccessSubject Area:
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Mauro C. Wesseling, Lisa Wagner-Britz, Duc Bach Nguyen, Salome Asanidze, Judy Mutua, Nagla Mohamed, Benjamin Hanf, Mehrdad Ghashghaeinia, Lars Kaestner, Ingolf Bernhardt
Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2016) 39 (5): 1941–1954.
Published Online: 24 October 2016
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phosphatidylserine exposure Protein kinase C Flow cytometry Fluorescence imaging Red blood cells Ca 2+ content...
Journal Articles
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2015) 36 (2): 555–568.
Published Online: 18 May 2015
... pretreatment abolished the inhibitory effects of NF-1 on I Ca,L . Protein kinase C (PKC) antagonists abolished NF-1-induced responses, whereas inhibition of PKA activity or intracellular application of the fast Ca 2+ -chelator BAPTA elicited no such effects. Application of NF-1 increased membrane abundance...
Journal Articles
Evaluating Sphingosine and its Analogues as Potential Alternatives for Aggressive Lymphoma Treatment
Open AccessSubject Area:
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2014) 34 (5): 1686–1700.
Published Online: 07 November 2014
... growth independently of S1P receptors in different DLBCL cell lines. Three different modes of Sph-mediated cell death were observed: Apoptosis, autophagy, and protein kinase C (PKC) inhibition. Generation of pro-apoptotic Cer accounted only for a minor portion of the apoptotic rate. Conclusion: Sph...
Journal Articles
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2014) 33 (2): 513–527.
Published Online: 20 February 2014
... using a live-cell fluorescence imaging system. Protein kinase C (PKC) isoforms and Ca 2+ -handling proteins were analysed using immunofluorescence and western blotting. Results: After IH exposure for 4 days, the rate of Ca 2+ extrusion from the cytosol to the extracellular milieu during 40-mM KCl...
Journal Articles
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2014) 33 (2): 300–309.
Published Online: 31 January 2014
... and β position. Methods: Activities of protein kinase C (PKC) and protein phosphatases such as protein phosphatase 1 (PP1), PP2A, and protein tyrosine phosphatase 1B (PTP1B) were assayed under the cell-free conditions and in PC-12 cells. Akt1/2 activity was monitored by quantifying phosphorylation...
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 32 (6): 1830–1844.
Published Online: 16 December 2013
...-pipette seal. Leak currents, if any, were subtracted and series resistance and capacitance were efficiently compensated. Vitamin E MnTBAP HERG Protein kinase A Protein kinase C Reactive oxygen species (ROS) The physiological function of the K + currents carried by the channel...
Journal Articles
Protein Kinase Cα and P-Type Ca 2+ Channel Ca V 2.1 in Red Blood Cell Calcium Signalling
Open AccessSubject Area:
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 31 (6): 883–891.
Published Online: 12 June 2013
... for the number of cells with Ca 2+ elevation was 2.7±1.2 µM; for phosphatidylserine exposure to the external membrane surface, it was 2.8±0.5 µM; and for RBC haemolysis, it was 2.9±0.5 µM. Using pharmacological manipulation with the Ca V 2.1 inhibitor ω-agatoxin TK and the broad protein kinase C inhibitor Gö6983...
Journal Articles
Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases
Open AccessSubject Area:
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 31 (4-5): 555–564.
Published Online: 05 April 2013
... Protein tyrosine phosphatase 1B DCP-LA-phospholipid Protein kinase C Protein phosphatase 1 8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), our originally synthesized linoleic acid derivative, serves as a selective activator of protein kinase Cε (PKCε) [ 1,2 ]. DCP-LA...
Journal Articles
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 31 (4-5): 532–541.
Published Online: 03 April 2013
..., the protein kinase C (PKC), showed opposing effects on mouse HCN1 channels expressed in Xenopus oocytes. Methods: In order to study PKC effects on HCN1 mediated currents in a mammalian environment we expressed rat HCN1 or human HCN1 in human embryonic kidney (HEK293) cells and rat HCN1 in murine neuroblastoma...
Journal Articles
Linoleic Acid Derivative DCP-LA Stimulates Vesicular Transport of α7 ACh Receptors towards Surface Membrane
Available to PurchaseSubject Area:
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (1): 75–82.
Published Online: 08 June 2012
... potentiated α7 ACh receptor currents, and the effect was inhibited by a protein kinase C (PKC) inhibitor or vesicular transport inhibitors. DCP-LA did not induce PKC phosphorylation of α7 ACh receptors. DCP-LA stimulated translocation of α7 ACh receptors from the cytosol toward the plasma membrane or from...
Journal Articles
Indomethacin Activates Protein Kinase C and Potentiates α7 ACh Receptor Responses
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 29 (1-2): 189–196.
Published Online: 01 March 2012
..., instructions or products referred to in the content or advertisements. Indomethacin Protein kinase C α7 ACh receptor Hippocampal synaptic transmission Facilitation Cellular Physiology and Biochemistry Original Paper Cell Physiol Biochem 2012;29:189-196 Accepted: December 27, 2011 Indomethacin...
Journal Articles
Cardiac Actin Capping Protein Reduction and Protein Kinase C Inhibition Maintain Myofilament Function During Cardioplegic Arrest
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2011) 27 (3-4): 263–272.
Published Online: 01 April 2011
...Feng Hua Yang; W. Glen Pyle Background: Heart transplantation is associated with cold, cardioplegic arrest that impairs myocardial function. Protein Kinase C (PKC) suppression of myofilaments may contribute to this dysfunction. CapZ-deficient cardiac myofilaments are unresponsive to PKC. We...
Journal Articles
Auto-Positive Feedback Regulation for Nicotinic Acetylcholine Receptors by Protein Kinase C Activation
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2006) 26 (2): 247–252.
Published Online: 24 August 2010
...Kosuke Yamada; Takahiro Yaguchi; Takeshi Kanno; Takeshi Mukasa; Tomoyuki Nishizaki Background/Aims: Protein kinase C (PKC) is well-recognized to modify ligand-gated ion channels such as nicotinic ACh (nACh) receptors by phosphorylating the receptors. The aim of the present study was to obtain...
Journal Articles
Higher Concentrations of Extracellular ATP Suppress Proliferation of Caco-2 Human Colonic Cancer Cells via an Unknown Receptor Involving PKC Inhibition
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2006) 26 (2): 125–134.
Published Online: 24 August 2010
... Protein kinase C Mitogen-activated protein kinase Caco-2 cell Proliferation Abstract Background/Aims: Adenosine 5 -triphosphate (ATP) mediates a variety of signal transductions via ATP receptors such as P2X and P2Y receptors. The present study aimed at understanding the mechanism underlying...
Journal Articles
Functional Study of CLC-1 Mutants Expressed in Xenopus Oocytes Reveals that a C-terminal Region Thr891-Ser892-Thr893 is Responsible for the Effects of Protein Kinase C Activator
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Journal:
Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2006) 25 (6): 687–694.
Published Online: 18 May 2010
...Kuang-Ming Hsiao; Ren-Yu Huang; Pei-Hua Tang; Min-Jon Lin ClC-1 plays an important part in the maintenance of membrane potential in the mammalian skeletal muscle. To investigate the phosphorylation sites responsible for the effect of PKC (protein kinase C) activator, we constructed 21 different ClC...
Journal Articles
Regulation of Renin Secretion and Renin Synthesis by Second Messengers in Isolated Mouse Juxtaglomerular Cells
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Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (1991) 1 (2): 98–110.
Published Online: 04 September 2008
... secretion and synthesis in parallel. With this experimental model, we have examined whether renin synthesis and secretion are concordantly regulated by second-messenger molecules such as cyclic nucleotides and protein kinase C. We found that 8-bromo-cyclic GMP (8-bromo-cGMP; 100 µ M ) inhibited...
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