... suppressed the progression of EMT, proliferation, migration, and invasion of colon cancer cells in vitro and tumor growth in vivo . ZEB1 silencing blocked CUL4A-driven these processes. Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1...

... Hepatocellular carcinoma Prognosis Meta-analysis Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in men and is the sixth most common cause in women worldwide [ 1 ]. East Asia and Africa have the highest rates of HCC in the world [ 2 ]. Nearly 55% of all HCC cases...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Liver failure Predictor Prognosis Hepatitis B virus ABIC score Acute-on-chronic liver failure (ACLF...

...Cheng Zhang; Yu Liang; Ming-Hui Ma; Kun-Zhe Wu; Chun-Dong Zhang; Dong-Qiu Dai Background/Aims: MicroRNAs have a significant role in the tumorigenesis and progression of cancers, including gastric cancer (GC). Our study aimed to identify a novel biomarker to predict the prognosis of patients with GC...

... populations. Meta-analysis was performed to evaluate the association of IGF2BP2 and prognosis. Lentivirus-based shRNAs were used to knock down IGF2BP2 in AML cell lines KG-1a and Kasumi. Results: We searched the public database Gene Omnibus and analyzed IGF2BP2 expression in both AML and healthy populations...

... Predictive marker Prognosis Meta-analysis According to a recent epidemiological report, colorectal cancer (CRC) is still one of the most impactful diseases worldwide, as the third most diagnosed cancer and the fourth leading cause of cancer-related death [ 1 ]. Currently, therapeutic strategies...

... serve as a novel positive factor for malignant patient prognosis in Chinese population. [email protected] 20 08 2018 12 11 2018 22 11 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access License / Drug Dosage / Disclaimer This article...

... as a potential biomarker for the prognosis of patients with HCC. [email protected] 28 03 2018 9 11 2018 19 11 2018 © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons...

...-time PCR, western blotting and Co-immunoprecipitation assay. Results: DCLK1 is overexpressed in pancreatic cancer and is related to metastasis and prognosis. Knockdown of DCLK1 markedly suppressed cell growth in vitro and in vivo and also inhibited the migration and invasion of pancreatic cancer cells...

...-mediated upregulation of Twist1, cell migration and invasion. A strong positive correlation between TPPP3 and Twist1 expression was identified in NSCLC tissues. Patients with low TPPP3 or low Twist1 in NSCLC tissues had a better prognosis with longer overall survival (OS) and disease-free survival (DFS...

... expression and CRC disease free survival (DFS) were evaluated through univariate Cox regression analysis, and prognosis signature constructed by combination of weighted lncRNA expression values were obtained through multivariate Cox regression analysis. Robustness of the prognosis signature was evaluated...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. LncRNA The Cancer Genome Atlas (TCGA) Bladder urothelial cancer (BLCA) Prognosis Bladder urothelial cancer (BLCA) is the fourth most common cancer in males...

..., instructions or products referred to in the content or advertisements. CDKN2A Methylation Head and neck squamous cell carcinoma Diagnosis Prognosis Carcinogenesis Cancer of the head and neck region is the sixth most common cancer and fifth leading cause of cancer-related death worldwide...

... and tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment and to determine their combined effect on prognosis of laryngeal cancer (LC). Methods: The tumor-cell expression scores and TIL positivity ratiosof IL-12Rβ2 and IL-23R in matched LC and normal laryngeal tissue samples from 61 LC...

... explored the correlation of promoter methylation of the Ezrin gene with the incidence and prognosis of CC. Methods: Cervical tissues from a total of 483 patients with CC were collected from the China-Japan Union Hospital of Jilin University. Samples were assigned into four groups accordingly...

...Qingyan Mao; Zhen Chen; Kun Wang; Renfang Xu; Hao Lu; Xiaozhou He Background/Aims: Several recent studies have demonstrated that Stathmin 1expression may be closely associated with prognosis in patients with various types of cancers. In the present study, we conducted a meta-analysis of all...

... with prognosis. However, estrogen receptor and progesterone receptor status were found to be positively correlated with MEG3 expression. Conversely, basal-like status, triple-negative breast cancer status, and Scarff Bloom & Richardson grade criterion were negatively correlated with MEG3 expression...

... tissues and adjacent normal lung tissues. Patients’ prognosis was evaluated using overall survival. The prognostic role of MARCH9 was tested with univariate and multivariate analyses. To confirm the effect of MARCH9 in cell proliferation and invasion, overexpression of MARCH9 was induced in two LAC cell...

... stages (Cox p < 0.0001). Conclusion: The novel network-based, integrative analysis adopted in this study was efficient in screening for prognostic predictors. Along with PI, the set of 6 miRNAs, 11 mRNAs, and 9 DNA methylation sites could serve as the basis for improved prognosis estimation for CRC...

... analysis revealed that splenic rupture and adjuvant chemotherapy were independent adverse and favorable predictors, respectively. Conclusion: Our large series describes and confirms the characteristics and poor prognosis of Chinese primary splenic angiosarcoma, thus indicating a critical role for early...