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Keywords: Poly (ADP)-ribose polymerase
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Journal Articles

Relative Quantitative Comparison between Lipotoxicity and Glucotoxicity Affecting the PARP-NAD-SIRT1 Pathway in Hepatocytes

Subject Area:
Topic Article Package: Diabetes , Further Areas
Jing Pang, Chao Xi, Junhua Jin, Yiwen Han, Tie-mei Zhang
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 32 (3): 719–727.
https://doi.org/10.1159/000354474
Published Online: 13 September 2013
... (OA) and glucose on poly (ADP)-ribose polymerase (PARP) and SIRT1 expression. HepG2 cells were stimulated using 500 µM OA with 5.5 mM glucose or 30 mM glucose for 1 day. PARP expression, PARP activity (PAR) and SIRT1 expression were detected by western blotting. The combination of OA and 30 mM glucose...
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