...Kodai Uematsu; Yukiko Enomoto; Takashi Onuma; Masanori Tsujimoto; Tomoaki Doi; Rie Matsushima-Nishiwaki; Haruhiko Tokuda; Shinji Ogura; Hiroki Iida; Osamu Kozawa; Toru Iwama Background/Aims: Thrombin induces the activation of human platelets through protease-activated receptor (PAR) 1 and PAR4...

... stenosis and sham control groups of our successfully developed atherothrombosis mouse models before thrombosis. Platelets from healthy volunteers and mice were purified to obtain thrombin stimulated platelet-derived exosomes. Exosomes were isolated via differential ultracentrifugation, and western blotting...

...Bernhard Hermann Rauch Sphingosine 1-phosphate (S1P) is a multifunctional signaling lipid generated from sphingosine by sphingosine kinases. S1P formation has been shown in numerous cells in the circulation, including platelets, vascular endothelial and smooth muscle cells and monocytes. S1P also...

...H.Y. Cheng; M. Magocsi; R.S. Cooper; J.T. Penniston; J.L. Borke Human megakaryoblastic cells (platelet precursor cells) grown in culture were sectioned for immunohistochemistry. Incubating these cells with a monoclonal antibody (JA8) directed against the human erythrocyte Ca 2+ pump showed specific...