... duct cells. manoocher.soleimani@uc.edu 23 01 2018 17 10 2018 24 10 2018 Collecting duct Crispr/Cas9 Pendrin Acid base regulation © 2018 The Author(s). Published by S. Karger AG, Basel 2018 Open Access License / Drug Dosage / Disclaimer This article is licensed...

... - concentration vs. WT animals (29.26 mEq/L in CF mice vs. 26.72 in WT; n=5, p=0.0291). Immunofluorescence labeling demonstrated a profound reduction in the apical expression of the Cl - /HCO 3 - exchanger pendrin in cortical collecting duct cells and western and northern blots indicated diminished plasma...

...Emanuele Bernardinelli; Roberta Costa; Charity Nofziger; Markus Paulmichl; Silvia Dossena Background/Aims: Pendrin is a Cl - /I - /HCO 3 - exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment...

... in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex. Since co-expression of AQP5 and pendrin in the apical membrane domain is a common feature of several other epithelia such as cochlear and bronchial epithelial cells, we evaluated here...

...Grazia Tamma; Marianna Ranieri; Silvia Dossena; Annarita Di Mise; Charity Nofziger; Maria Svelto; Markus Paulmichl; Giovanna Valenti Background: Human pendrin (SLC26A4, PDS) is an integral membrane protein acting as an electroneutral anion exchanger. Loss of function mutations in pendrin protein...

... it co-localizes with pendrin. No basolateral AQPs were detected in type-B intercalated cells, suggesting that AQP5 is unlikely to be involved in the net trans-epithelial water reabsorption occurring in the distal tubule. An intriguing hypothesis is that AQP5 may serve an osmosensor for the composition...

... and in the lumen at the apical side. The first step is mediated by the Na + /I - symporter (NIS). In most reviews and textbooks, the second step is presented as mediated by pendrin. In this review, we analyze this assumption. There are several arguments supporting the concept that indeed pendrin plays an important...

...Silvia Dossena; Charity Nofziger; Grazia Tamma; Emanuele Bernardinelli; Simone Vanoni; Christoph Nowak; Elisabeth Grabmayer; Sonja Kössler; Susanne Stephan; Wolfgang Patsch; Markus Paulmichl Pendrin (SLC26A4, PDS) is an electroneutral anion exchanger transporting I - , Cl - , HCO 3 - , OH - , SCN...

... on the specific subtype. The activity of H + -ATPases is regulated by acid-base status and several hormones, including angiotensin II and aldosterone. Angiotensin II stimulates chloride absorption mediated by pendrin in type B intercalated cells and this process is energized by the activity of H + -ATPases...

...Silvia Dossena; Aigerim Bizhanova; Charity Nofziger; Emanuele Bernardinelli; Josef Ramsauer; Peter Kopp; Markus Paulmichl Background: Pendrin is a multifunctional anion transporter that exchanges chloride and iodide in the thyroid, as well as chloride and bicarbonate in the inner ear, kidney...

...Aigerim Bizhanova; Peter Kopp Pendred syndrome is an autosomal recessive disorder defined by sensorineural deafness, goiter and a partial organification defect of iodide. It is caused by biallelic mutations in the multifunctional anion transporter pendrin/SLC26A4. In human thyroid tissue, pendrin...

...Simona Rodighiero; Guido Bottà; Claudia Bazzini; Giuliano Meyer The pendrin ( SLC26A4 or PDS) gene is responsible, when mutated, for the Pendred syndrome, a recessive disorder characterized by sensorineural hearing loss often accompanied by thyroid dysfunctions. Pendrin protein is an anion...

...Silvia Dossena; Charity Nofziger; Zippora Brownstein; Moien Kanaan; Karen B. Avraham; Markus Paulmichl Background: Pendrin is a transport protein exchanging chloride for other anions, such as iodide in the thyroid gland or bicarbonate in the inner ear. Mutations in the SLC26A4 gene encoding...

...Silvia Dossena; Charity Nofziger; Florian Lang; Giovanna Valenti; Markus Paulmichl Human pendrin (SCL26A4, PDS) is a 780 amino acid integral membrane protein with transport function. It acts as an electroneutral, sodium-independent anion exchanger for a wide range of anions, such as iodide...

...Aigerim Bizhanova; Teng-Leong Chew; Satya Khuon; Peter Kopp Background: Iodide uptake at the basolateral membrane and iodide efflux at the apical membrane of thyrocytes, essential steps in the biosynthesis of thyroid hormone, are stimulated by thyroid stimulating hormone (TSH). Pendrin (SLC26A4...