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Keywords: PTEN/Akt
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Journal Articles

Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer

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Chunfeng Pan, Guoliang Yao, Bin Liu, Teng Ma, Yang Xia, Ke Wei, Jun Wang, Jin Xu, Liang Chen, Yijiang Chen
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2017) 43 (1): 339–352.
https://doi.org/10.1159/000480414
Published Online: 31 August 2017
... inhibited cell proliferation, invasion, migration and EMT via the PTEN/AKT pathway. Furthermore, an in vivo assay confirmed that overexpression of FAL1 facilitated tumor growth and metastasis. Conclusion: FAL1 may promote tumorigenesis and progression of NSCLC through the PTEN/AKT axis, which could lead...
View articletitled, Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer
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Journal Articles

Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma

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Lu Wang, Lei Yang, Ying Lu, Yingzhun Chen, Tianhua Liu, Yanli Peng, Yuhong Zhou, Yang Cao, Zhenggang Bi, Tianyi Liu, Zhenhong Liu, Hongli Shan
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2016) 38 (6): 2173–2182.
https://doi.org/10.1159/000445573
Published Online: 17 May 2016
... inhibited by osthole in a dose- and time-dependent manner. Cell cycle was arrested and the ability of migration and invasion was obviously reduced when cells were exposed to osthole. Moreover, enzymes involved in PTEN/Akt pathway were regulated such as PTEN and p-Akt proteins. Furthermore, osthole inhibited...
View articletitled, Osthole Induces Cell Cycle Arrest and Inhibits Migration and Invasion via PTEN/Akt Pathways in Osteosarcoma
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